| pubmed-article:17349932 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0208355 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0020281 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17349932 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17349932 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17349932 | pubmed:dateCreated | 2007-3-12 | lld:pubmed |
| pubmed-article:17349932 | pubmed:abstractText | We investigated nitric oxide (*NO)-mediated proteosomal activation in bovine aortic endothelial cells (BAEC) treated with varying fluxes of hydrogen peroxide (H(2)O(2)) generated from glucose/glucose oxidase (Glu/GO). Results revealed a bell-shaped *NO signaling response in BAEC treated with Glu/GO (2-20 mU/ml). GO treatment (2 mU/ml) enhanced endothelial nitric oxide synthase (eNOS) phosphorylation and *NO release in BAEC. With increasing GO concentrations, phospho eNOS and *NO levels decreased. Bell-shaped responses in proteasomal function and *NO induction were observed in BAEC treated with varying levels of GO (2-10 mU/ml). Proteosomal activation induced in GO-treated BAEC was inhibited by N(omega)-nitro-L-arginine-methyl ester pretreatment, suggesting that *NO mediates proteasomal activation. Intracellular *NO induced by H(2)O(2) was detected by isolating the 4,5-diaminoflourescein (DAF-2)/*NO/O(2)-derived "green fluorescent product" using the high-performance liquid chromatography-fluorescence technique, a more rigorous and quantitative methodology for detecting the DAF-2/*NO/O(2) reaction product. Finally, the relationships between H(2)O(2) flux, proteasomal activation/inactivation, endothelial cell survival, and apoptosis are discussed. | lld:pubmed |
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| pubmed-article:17349932 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17349932 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17349932 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17349932 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17349932 | pubmed:issn | 0891-5849 | lld:pubmed |
| pubmed-article:17349932 | pubmed:author | pubmed-author:KalyanaramanB... | lld:pubmed |
| pubmed-article:17349932 | pubmed:author | pubmed-author:HarderDavid... | lld:pubmed |
| pubmed-article:17349932 | pubmed:author | pubmed-author:KotamrajuSrig... | lld:pubmed |
| pubmed-article:17349932 | pubmed:author | pubmed-author:ThomasSimmyS | lld:pubmed |
| pubmed-article:17349932 | pubmed:author | pubmed-author:ZielonkaJacek... | lld:pubmed |
| pubmed-article:17349932 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17349932 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17349932 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:17349932 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17349932 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17349932 | pubmed:pagination | 1049-61 | lld:pubmed |
| pubmed-article:17349932 | pubmed:dateRevised | 2011-2-16 | lld:pubmed |
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| pubmed-article:17349932 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17349932 | pubmed:articleTitle | Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. | lld:pubmed |
