| pubmed-article:17344014 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C2828366 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C1705851 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C1269316 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C1555707 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0720930 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C0069832 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C1096918 | lld:lifeskim |
| pubmed-article:17344014 | lifeskim:mentions | umls-concept:C2752151 | lld:lifeskim |
| pubmed-article:17344014 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17344014 | pubmed:dateCreated | 2007-4-16 | lld:pubmed |
| pubmed-article:17344014 | pubmed:abstractText | A high-performance liquid chromatographic method was developed and validated for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma. The coumarin components and the internal standard isopsoralen were extracted from plasma samples with the mixture of tert-butyl methyl ether and n-hexane (4:1, v/v). Chromatographic separation was performed on a C(18) column (200 mm x 4.6mm, 5 microm) with the mobile phase acetonitrile-methanol-water-acetic acid (20:15:65:2, v/v/v/v) at a flow-rate of 1.0 ml/min. Only the peak of oxypeucedanin hydrate and byak-angelicin could be detected in dog plasma after oral administration of ethanol extracts of A. dahurica mainly containing xanthotoxol, osthenol, imperatorin, oxypeucedanin hydrate and byak-angelicin. The calibration curves of oxypeucedanin hydrate and byak-angelicin were linear over a range of 22.08-8830.00 and 6.08-2430.00 ng/ml in dog plasma, respectively. The quantification limit of oxypeucedanin hydrate and byak-angelicin in dog plasma was 22.08 and 6.08 ng/ml, respectively. The intra- and inter-day precision was less than 7.6% and 8.5% and the accuracy was from 91.9% to 106.1%. The lowest absolute recoveries of oxypeucedanin hydrate and byak-angelicin were 85.7% and 87.0%, respectively. The method was successfully applied to the pharmacokinetic studies of oxypeucedanin hydrate and byak-angelicin in dog plasma after oral administration of ethanol extracts from A. dahurica. | lld:pubmed |
| pubmed-article:17344014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17344014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17344014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17344014 | pubmed:month | May | lld:pubmed |
| pubmed-article:17344014 | pubmed:issn | 0731-7085 | lld:pubmed |
| pubmed-article:17344014 | pubmed:author | pubmed-author:HanK JKJ | lld:pubmed |
| pubmed-article:17344014 | pubmed:author | pubmed-author:FengZ LZL | lld:pubmed |
| pubmed-article:17344014 | pubmed:author | pubmed-author:ThoT DTD | lld:pubmed |
| pubmed-article:17344014 | pubmed:author | pubmed-author:WuYutianY | lld:pubmed |
| pubmed-article:17344014 | pubmed:author | pubmed-author:XieYingY | lld:pubmed |
| pubmed-article:17344014 | pubmed:author | pubmed-author:FanGuorongG | lld:pubmed |
| pubmed-article:17344014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17344014 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:17344014 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:17344014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17344014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17344014 | pubmed:pagination | 166-72 | lld:pubmed |
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| pubmed-article:17344014 | pubmed:meshHeading | pubmed-meshheading:17344014... | lld:pubmed |
| pubmed-article:17344014 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17344014 | pubmed:articleTitle | High-performance liquid chromatographic method for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma. | lld:pubmed |
| pubmed-article:17344014 | pubmed:affiliation | Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China. | lld:pubmed |
| pubmed-article:17344014 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17344014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
