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pubmed-article:17340661pubmed:abstractTextThis manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly(ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique-which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries-has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.lld:pubmed
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pubmed-article:17340661pubmed:articleTitleImmunoisolating pancreatic islets by encapsulation with selective withdrawal.lld:pubmed
pubmed-article:17340661pubmed:affiliationThe James Franck Institute and Department of Physics, The University of Chicago, Chicago, IL 60637, USA.lld:pubmed
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