pubmed-article:17329235 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17329235 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:17329235 | lifeskim:mentions | umls-concept:C0312740 | lld:lifeskim |
pubmed-article:17329235 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
pubmed-article:17329235 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
pubmed-article:17329235 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
pubmed-article:17329235 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:17329235 | pubmed:dateCreated | 2007-3-30 | lld:pubmed |
pubmed-article:17329235 | pubmed:abstractText | Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4(+)CD25(+) T regulatory cells (nTregs). In mice, expression of FoxP3 is strictly correlated with regulatory activity, whereas increasing evidence suggests that in humans, activated T effector cells (Teffs) may also express FOXP3. In order to better define the role of FOXP3 in human Teff cells, we investigated the intensity and kinetics of expression in ex vivo Teff cells, suppressed Teff cells and Teff cell lines. We found that all dividing Teff cells expressed FOXP3, but only transiently, and at levels that were significantly lower than those in suppressive nTregs. This temporary expression in Teff cells was insufficient to suppress expression of reported targets of FOXP3 repressor activity, including CD127, IL-2 and IFN-gamma, and was not correlated with induction of a nTreg phenotype. Thus expression of FOXP3 is a normal consequence of CD4(+) T cell activation and, in humans, it can no longer be used as an exclusive marker of nTregs. These data indicate that our current understanding of how FOXP3 contributes to immune tolerance in humans needs to be re-evaluated. | lld:pubmed |
pubmed-article:17329235 | pubmed:language | eng | lld:pubmed |
pubmed-article:17329235 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17329235 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17329235 | pubmed:month | Apr | lld:pubmed |
pubmed-article:17329235 | pubmed:issn | 0953-8178 | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:PasseriniLaur... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:SteinerTheodo... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:BacchettaRosa... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:LevingsMegan... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:RoncaroloMari... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:AllanSarah... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:CrellinNatash... | lld:pubmed |
pubmed-article:17329235 | pubmed:author | pubmed-author:CromeSarah... | lld:pubmed |
pubmed-article:17329235 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17329235 | pubmed:volume | 19 | lld:pubmed |
pubmed-article:17329235 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17329235 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17329235 | pubmed:pagination | 345-54 | lld:pubmed |
pubmed-article:17329235 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:meshHeading | pubmed-meshheading:17329235... | lld:pubmed |
pubmed-article:17329235 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17329235 | pubmed:articleTitle | Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. | lld:pubmed |
pubmed-article:17329235 | pubmed:affiliation | Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada. | lld:pubmed |
pubmed-article:17329235 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17329235 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:50943 | entrezgene:pubmed | pubmed-article:17329235 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17329235 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17329235 | lld:pubmed |