| pubmed-article:17325901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17325901 | lifeskim:mentions | umls-concept:C0024305 | lld:lifeskim |
| pubmed-article:17325901 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:17325901 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17325901 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17325901 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17325901 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17325901 | pubmed:dateCreated | 2007-2-27 | lld:pubmed |
| pubmed-article:17325901 | pubmed:abstractText | Cyclooxygenase 2 (Cox-2) is a key enzyme in prostaglandin synthesis and it has an important role in the pathogenesis of various malignancies. Cox-2 has been studied in solid tumors; however, studies about the role of Cox-2 in non-Hodgkin's lymphomas (NHL) are limited. The aim of this study is to determine the importance of Cox-2 expression in lymphomas. To this end, Cox-2 expression was determined in 177 cases with NHL. In histological terms, 60 cases (33%) had low grade and 117 (67%) had aggressive lymphoma. Ninety-nine cases were found to be positive for Cox-2 (56%); Cox-2 score was between 50 and 100, 101 and 200 and over 200 in 38, 46 and 15 cases, respectively. There was an important association between aggressive histology and Cox-2 expression: Cox-2 was negative in about half of the cases with indolent morphology, while two thirds of the Cox-2 positive cases had aggressive histology (p = 0.036). There was no significant association between Cox-2 expression and clinical-laboratory parameters. Although the overall survival times were longer in cases with lower or no Cox-2 expression as compared with higher Cox-2 expression, the difference was not significant. In conclusion Cox-2 expression is seen about 60% of the cases with NHL and is associated with aggressive morphology. | lld:pubmed |
| pubmed-article:17325901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17325901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17325901 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17325901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17325901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17325901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17325901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17325901 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17325901 | pubmed:issn | 1042-8194 | lld:pubmed |
| pubmed-article:17325901 | pubmed:author | pubmed-author:PaydasSemraS | lld:pubmed |
| pubmed-article:17325901 | pubmed:author | pubmed-author:ErginMelekM | lld:pubmed |
| pubmed-article:17325901 | pubmed:author | pubmed-author:SeydaogluGuls... | lld:pubmed |
| pubmed-article:17325901 | pubmed:author | pubmed-author:ErdoganSeydaS | lld:pubmed |
| pubmed-article:17325901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17325901 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:17325901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17325901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17325901 | pubmed:pagination | 389-95 | lld:pubmed |
| pubmed-article:17325901 | pubmed:dateRevised | 2009-11-3 | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
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| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:meshHeading | pubmed-meshheading:17325901... | lld:pubmed |
| pubmed-article:17325901 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17325901 | pubmed:articleTitle | Cyclooxygenase-2 expression in non-Hodgkin's lymphomas. | lld:pubmed |
| pubmed-article:17325901 | pubmed:affiliation | Department of Oncology, Faculty of Medicine, Cukurova University, Adana, Turkey. sepay@cu.edu.tr | lld:pubmed |
| pubmed-article:17325901 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17325901 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5743 | entrezgene:pubmed | pubmed-article:17325901 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17325901 | lld:entrezgene |
| lhgdn:association:30231 | lhgdn:found_in | pubmed-article:17325901 | lld:lhgdn |
