pubmed-article:17325668 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C0755105 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1261552 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
pubmed-article:17325668 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
pubmed-article:17325668 | pubmed:issue | 7137 | lld:pubmed |
pubmed-article:17325668 | pubmed:dateCreated | 2007-4-12 | lld:pubmed |
pubmed-article:17325668 | pubmed:abstractText | Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mechanisms of entry into host cells, is needed to identify novel therapeutic targets. Although HCV entry requires the CD81 co-receptor, and other host molecules have been implicated, at least one factor critical to this process remains unknown (reviewed in refs 1-3). Using an iterative expression cloning approach we identified claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, as essential for HCV entry. CLDN1 is required for HCV infection of human hepatoma cell lines and is the first factor to confer susceptibility to HCV when ectopically expressed in non-hepatic cells. Discrete residues within the first extracellular loop (EL1) of CLDN1, but not protein interaction motifs in intracellular domains, are critical for HCV entry. Moreover, antibodies directed against an epitope inserted in the CLDN1 EL1 block HCV infection. The kinetics of this inhibition indicate that CLDN1 acts late in the entry process, after virus binding and interaction with the HCV co-receptor CD81. With CLDN1 we have identified a novel key factor for HCV entry and a new target for antiviral drug development. | lld:pubmed |
pubmed-article:17325668 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:language | eng | lld:pubmed |
pubmed-article:17325668 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17325668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17325668 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17325668 | pubmed:month | Apr | lld:pubmed |
pubmed-article:17325668 | pubmed:issn | 1476-4687 | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:BieniaszPaul... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:WölkBennoB | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:SyderAndrew... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:RiceCharles... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:McKeatingJane... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:HatziioannouT... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:TscherneDonna... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:EvansMatthew... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:von... | lld:pubmed |
pubmed-article:17325668 | pubmed:author | pubmed-author:PanisMaryline... | lld:pubmed |
pubmed-article:17325668 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:17325668 | pubmed:day | 12 | lld:pubmed |
pubmed-article:17325668 | pubmed:volume | 446 | lld:pubmed |
pubmed-article:17325668 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17325668 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17325668 | pubmed:pagination | 801-5 | lld:pubmed |
pubmed-article:17325668 | pubmed:dateRevised | 2007-10-23 | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:meshHeading | pubmed-meshheading:17325668... | lld:pubmed |
pubmed-article:17325668 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17325668 | pubmed:articleTitle | Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. | lld:pubmed |
pubmed-article:17325668 | pubmed:affiliation | Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA. | lld:pubmed |
pubmed-article:17325668 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17325668 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:17325668 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
entrez-gene:9076 | entrezgene:pubmed | pubmed-article:17325668 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17325668 | lld:entrezgene |
lhgdn:association:25663 | lhgdn:found_in | pubmed-article:17325668 | lld:lhgdn |
lhgdn:association:25674 | lhgdn:found_in | pubmed-article:17325668 | lld:lhgdn |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17325668 | lld:pubmed |