| pubmed-article:17325659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C1325410 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C1420236 | lld:lifeskim |
| pubmed-article:17325659 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:17325659 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:17325659 | pubmed:dateCreated | 2007-8-9 | lld:pubmed |
| pubmed-article:17325659 | pubmed:abstractText | Anchorage-independent growth is a hallmark of tumor growth and results from enhanced proliferation and altered cell-cell and cell-matrix interactions. By using gene-deficient mouse embryonic fibroblasts (MEFs), we showed for the first time that NHERF1/EBP50 (Na/H exchanger regulator factor 1/ezrin-radixin-moesin binding phosphoprotein 50), an adapter protein with membrane localization under physiological conditions, inhibits cell motility and is required to suppress anchorage-independent growth. Both NHERF1 PDZ domains are necessary for the tumor suppressor effect. NHERF1 associates directly through the PDZ2 domain with beta-catenin and is required for beta-catenin localization at the cell-cell junctions in MEFs. Mechanistically, the absence of NHERF1 selectively decreased the interaction of beta-catenin with E-cadherin, but not with N-cadherin. The ensuing disorganization of E-cadherin-mediated adherens junctions as well as the observed moderate increase in beta-catenin transcriptional activity contributed most likely to the anchorage-independent growth of NHERF1-deficient MEFs. In vivo, NHERF1 is specifically localized at the apical brush-border membrane in intestinal epithelial cells and is required to maintain a fraction of the cortical beta-catenin at this level. Thus, NHERF1 emerges as a cofactor essential for the integrity of epithelial tissues by maintaining the proper localization and complex assembly of beta-catenin. | lld:pubmed |
| pubmed-article:17325659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17325659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17325659 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17325659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17325659 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17325659 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:17325659 | pubmed:author | pubmed-author:TakahashiYY | lld:pubmed |
| pubmed-article:17325659 | pubmed:author | pubmed-author:AdamsHH | lld:pubmed |
| pubmed-article:17325659 | pubmed:author | pubmed-author:McCreaP DPD | lld:pubmed |
| pubmed-article:17325659 | pubmed:author | pubmed-author:MoralesF CFC | lld:pubmed |
| pubmed-article:17325659 | pubmed:author | pubmed-author:KreimannE LEL | lld:pubmed |
| pubmed-article:17325659 | pubmed:author | pubmed-author:LiuT-JTJ | lld:pubmed |
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| pubmed-article:17325659 | pubmed:author | pubmed-author:GeorgescuM-MM... | lld:pubmed |
| pubmed-article:17325659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17325659 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:17325659 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17325659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17325659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17325659 | pubmed:pagination | 5290-9 | lld:pubmed |
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| pubmed-article:17325659 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17325659 | pubmed:articleTitle | Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. | lld:pubmed |
| pubmed-article:17325659 | pubmed:affiliation | Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:17325659 | pubmed:publicationType | Journal Article | lld:pubmed |
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