| pubmed-article:1732430 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1732430 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:1732430 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:1732430 | lifeskim:mentions | umls-concept:C1516213 | lld:lifeskim |
| pubmed-article:1732430 | lifeskim:mentions | umls-concept:C0039286 | lld:lifeskim |
| pubmed-article:1732430 | lifeskim:mentions | umls-concept:C0022203 | lld:lifeskim |
| pubmed-article:1732430 | lifeskim:mentions | umls-concept:C0048403 | lld:lifeskim |
| pubmed-article:1732430 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1732430 | pubmed:dateCreated | 1992-2-27 | lld:pubmed |
| pubmed-article:1732430 | pubmed:abstractText | The antiestrogen tamoxifen is effective in therapy for breast cancer. However, its use is limited by the eventual development of acquired tamoxifen resistance in many patients. The mechanisms responsible for tamoxifen resistance remain unknown; loss of estrogen receptor (ER), selection of hormone-independent breast cancer clones, or alterations in serum tamoxifen levels after long-term use do not explain acquired resistance in most patients. Using an experimental model in which human breast cancer cells develop resistance in athymic mice treated with tamoxifen, we have recently shown that acquired resistance is associated with markedly reduced cellular concentrations of tamoxifen and by isomerization of the trans-4-hydroxy metabolite to the less potent cis isomer. | lld:pubmed |
| pubmed-article:1732430 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1732430 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1732430 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1732430 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1732430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1732430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1732430 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1732430 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1732430 | pubmed:issn | 0732-183X | lld:pubmed |
| pubmed-article:1732430 | pubmed:author | pubmed-author:OsborneC KCK | lld:pubmed |
| pubmed-article:1732430 | pubmed:author | pubmed-author:CioccaD RDR | lld:pubmed |
| pubmed-article:1732430 | pubmed:author | pubmed-author:McGuireW LWL | lld:pubmed |
| pubmed-article:1732430 | pubmed:author | pubmed-author:DeGregorioM... | lld:pubmed |
| pubmed-article:1732430 | pubmed:author | pubmed-author:WiebeV JVJ | lld:pubmed |
| pubmed-article:1732430 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1732430 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1732430 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1732430 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1732430 | pubmed:pagination | 304-10 | lld:pubmed |
| pubmed-article:1732430 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
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| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
| pubmed-article:1732430 | pubmed:meshHeading | pubmed-meshheading:1732430-... | lld:pubmed |
| pubmed-article:1732430 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1732430 | pubmed:articleTitle | Tamoxifen and the isomers of 4-hydroxytamoxifen in tamoxifen-resistant tumors from breast cancer patients. | lld:pubmed |
| pubmed-article:1732430 | pubmed:affiliation | Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7884. | lld:pubmed |
| pubmed-article:1732430 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1732430 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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