pubmed-article:1731098 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
pubmed-article:1731098 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
pubmed-article:1731098 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:1731098 | pubmed:dateCreated | 1992-2-14 | lld:pubmed |
pubmed-article:1731098 | pubmed:abstractText | In this study, we show that CD4+, hepatitis B virus (HBV) envelope-specific T-cell clones produced by stimulation with a particulate antigen preparation are able to recognize and kill not only autologous antigen-presenting cells incubated with exogenous HBV envelope antigens but also autologous HLA class II-positive cells expressing endogenously synthesized HBV envelope antigens following infection with recombinant vaccinia viruses or transfection with recombinant Epstein-Barr virus expression vectors. Experiments with lysosomotropic agents and brefeldin A suggest that the endosomal compartment is likely involved in the processing of endogenously synthesized viral proteins for recognition by CD4+ T cells. Our study indicates that HBV envelope-specific, HLA class II-restricted CD4+ cytotoxic T lymphocytes can potentially participate in the immune clearance of HBV-infected cells and the pathogenesis of hepatocellular injury in hepatitis B. | lld:pubmed |
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pubmed-article:1731098 | pubmed:language | eng | lld:pubmed |
pubmed-article:1731098 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1731098 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:1731098 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1731098 | pubmed:month | Feb | lld:pubmed |
pubmed-article:1731098 | pubmed:issn | 0022-538X | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:MargolskeeR... | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:CavalliAA | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:FiaccadoriFF | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:MossBB | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:ChisariF VFV | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:FowlerPP | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:BertolettiAA | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:PennaAA | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:ValliAA | lld:pubmed |
pubmed-article:1731098 | pubmed:author | pubmed-author:GuilhotSS | lld:pubmed |
pubmed-article:1731098 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1731098 | pubmed:volume | 66 | lld:pubmed |
pubmed-article:1731098 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1731098 | pubmed:authorsComplete | N | lld:pubmed |
pubmed-article:1731098 | pubmed:pagination | 1193-8 | lld:pubmed |
pubmed-article:1731098 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:1731098 | pubmed:meshHeading | pubmed-meshheading:1731098-... | lld:pubmed |
pubmed-article:1731098 | pubmed:meshHeading | pubmed-meshheading:1731098-... | lld:pubmed |