| pubmed-article:17307162 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C0205753 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C1957335 | lld:lifeskim |
| pubmed-article:17307162 | lifeskim:mentions | umls-concept:C0057492 | lld:lifeskim |
| pubmed-article:17307162 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:17307162 | pubmed:dateCreated | 2007-3-9 | lld:pubmed |
| pubmed-article:17307162 | pubmed:abstractText | The antinociceptive effect of i.t. administered N(alpha)-amidino-Tyr-d-Arg-Phe-beta-Ala (amidino-TAPA), an N-terminal tetrapeptide analog of dermorphin, was characterized in ddY mice. In the opioid receptor ligand-binding assays using mouse brain membranes, amidino-TAPA showed a very high affinity for mu-opioid receptors, a low affinity to delta-opioid receptors and no affinity for kappa-opioid receptors. In the mouse tail-flick test, i.t. treatment with amidino-TAPA produced a potent antinociception. The antinociception induced by amidino-TAPA was significantly attenuated by i.t. pretreatment with the mu-opioid receptor antagonist beta-funaltrexamine, the kappa-opioid receptor antagonist nor-binaltorphimine and the delta-opioid receptor antagonist naltrindole. Moreover, the antinociception induced by amidino-TAPA was significantly attenuated by i.t. pretreatment with antisera against the endogenous kappa-opioid peptides dynorphin A, dynorphin B and alpha-neo-endorphin; and the endogenous delta-opioid peptide [Leu(5)]enkephalin. In mice lacking prodynorphin, the precursor of the endogenous kappa-opioid peptides, the antinociceptive effect of amidino-TAPA was significantly attenuated compared to that in wild-type C57BL/6J mice. However, there was no difference in G-protein activation by amidino-TAPA in the spinal cord membranes from prodynorphin knockout mice and C57BL/6J mice. The present results suggest that the spinal antinociception induced by the mu-opioid receptor selective peptide amidino-TAPA is mediated in part by the release of endogenous opioid peptides in the spinal cord, which is caused by the direct stimulation of mu-opioid receptors. | lld:pubmed |
| pubmed-article:17307162 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17307162 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17307162 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17307162 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17307162 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:SakuradaShino... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:SakuradaTsuka... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:MizoguchiHiro... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:WatanabeHiroy... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:WatanabeChizu... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:YonezawaAkihi... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:OhwadaKeikoK | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:MoriyamaKaori... | lld:pubmed |
| pubmed-article:17307162 | pubmed:author | pubmed-author:SatoBunseiB | lld:pubmed |
| pubmed-article:17307162 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17307162 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:17307162 | pubmed:volume | 560 | lld:pubmed |
| pubmed-article:17307162 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17307162 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17307162 | pubmed:pagination | 150-9 | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:meshHeading | pubmed-meshheading:17307162... | lld:pubmed |
| pubmed-article:17307162 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17307162 | pubmed:articleTitle | Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA. | lld:pubmed |
| pubmed-article:17307162 | pubmed:affiliation | Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. | lld:pubmed |
| pubmed-article:17307162 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17307162 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
