| pubmed-article:17306569 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17306569 | lifeskim:mentions | umls-concept:C0682638 | lld:lifeskim |
| pubmed-article:17306569 | lifeskim:mentions | umls-concept:C2702333 | lld:lifeskim |
| pubmed-article:17306569 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17306569 | pubmed:dateCreated | 2007-2-19 | lld:pubmed |
| pubmed-article:17306569 | pubmed:abstractText | More than half of the nascent B cells in humans initially express autoreactive antibodies. However, most of these autoantibodies are removed from the repertoire at two checkpoints before maturation into naive B cells. A third checkpoint excludes remaining autoantibodies from the antigen-experienced IgM(+) memory B cell pool. Nevertheless, low-affinity self-reactive antibodies are frequently found in the serum of normal humans. To determine the source of these antibodies, we cloned and expressed antibodies from circulating human IgG(+) memory B cells. Surprisingly, we found that self-reactive antibodies including anti-nuclear antibodies were frequently expressed by IgG(+) memory B cells in healthy donors. Most of these antibodies were created de novo by somatic hypermutation during the transition between mature naive and IgG(+) memory B cells. We conclude that deregulation of self-reactive IgG(+) memory B cells may be associated with autoimmunity. | lld:pubmed |
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| pubmed-article:17306569 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17306569 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17306569 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17306569 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17306569 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17306569 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17306569 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:17306569 | pubmed:author | pubmed-author:NussenzweigMi... | lld:pubmed |
| pubmed-article:17306569 | pubmed:author | pubmed-author:WardemannHedd... | lld:pubmed |
| pubmed-article:17306569 | pubmed:author | pubmed-author:TsuijiMakotoM | lld:pubmed |
| pubmed-article:17306569 | pubmed:author | pubmed-author:VelinzonKlara... | lld:pubmed |
| pubmed-article:17306569 | pubmed:author | pubmed-author:YurasovSergey... | lld:pubmed |
| pubmed-article:17306569 | pubmed:author | pubmed-author:TillerThomasT | lld:pubmed |
| pubmed-article:17306569 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17306569 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17306569 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17306569 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17306569 | pubmed:pagination | 205-13 | lld:pubmed |
| pubmed-article:17306569 | pubmed:dateRevised | 2011-6-1 | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:meshHeading | pubmed-meshheading:17306569... | lld:pubmed |
| pubmed-article:17306569 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17306569 | pubmed:articleTitle | Autoreactivity in human IgG+ memory B cells. | lld:pubmed |
| pubmed-article:17306569 | pubmed:affiliation | Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany. | lld:pubmed |
| pubmed-article:17306569 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17306569 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17306569 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
