| pubmed-article:1729761 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C0324939 | lld:lifeskim |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C0010206 | lld:lifeskim |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C0235378 | lld:lifeskim |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:1729761 | lifeskim:mentions | umls-concept:C0178849 | lld:lifeskim |
| pubmed-article:1729761 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:1729761 | pubmed:dateCreated | 1992-2-13 | lld:pubmed |
| pubmed-article:1729761 | pubmed:abstractText | The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome P-450 content and 7-ethoxycoumarin O-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. These data indicate that the gerbil is less sensitive to the hepatotoxic effects of coumarin than the rat. | lld:pubmed |
| pubmed-article:1729761 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1729761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1729761 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1729761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1729761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1729761 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1729761 | pubmed:issn | 0300-483X | lld:pubmed |
| pubmed-article:1729761 | pubmed:author | pubmed-author:FryJ RJR | lld:pubmed |
| pubmed-article:1729761 | pubmed:author | pubmed-author:ThomasN WNW | lld:pubmed |
| pubmed-article:1729761 | pubmed:author | pubmed-author:FentemJ HJH | lld:pubmed |
| pubmed-article:1729761 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1729761 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:1729761 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1729761 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1729761 | pubmed:pagination | 129-36 | lld:pubmed |
| pubmed-article:1729761 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:meshHeading | pubmed-meshheading:1729761-... | lld:pubmed |
| pubmed-article:1729761 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1729761 | pubmed:articleTitle | Species differences in the hepatotoxicity of coumarin: a comparison of rat and Mongolian gerbil. | lld:pubmed |
| pubmed-article:1729761 | pubmed:affiliation | Department of Physiology, Medical School, Queen's Medical Centre, Nottingham, U.K. | lld:pubmed |
| pubmed-article:1729761 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1729761 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1729761 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
