| pubmed-article:17297451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17297451 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17297451 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:17297451 | pubmed:dateCreated | 2007-7-19 | lld:pubmed |
| pubmed-article:17297451 | pubmed:abstractText | Scatter factor (SF) (hepatocyte growth factor) is a pleiotrophic cytokine that accumulates within tumors in vivo and protects tumor cells against cytotoxicity and apoptosis due to DNA damaging agents in vitro. Previous studies have established that SF-mediated cell protection involves antiapoptotic signaling from its receptor (c-Met) to PI3 kinase --> c-Akt --> Pak1 (p21-activated kinase -1) --> NF-kappaB (nuclear factor-kappa B). Here, we found that Ras proteins (H-Ras and R-Ras) enhance SF-mediated activation of NF-kappaB and protection of DU-145 and MDCK (Madin-Darby canine kidney) cells against the topoisomerase IIalpha inhibitor adriamycin. Studies of Ras effector loop mutants and their downstream effectors suggest that Ras/PI3 kinase and Ras/Raf1 pathways contribute to SF stimulation of NF-kappaB signaling and cell protection. Further studies revealed that Raf1 positively regulates the ability of SF to stimulate NF-kappaB activity and cell protection. The ability of Raf1 to stimulate NF-kappaB activity was not due to the classical Raf1 --> MEK1/2 --> ERK1/2 pathway. However, we found that a MEK3/6 --> p38 pathway contributes to SF-mediated activation of NF-kappaB. In contrast, RalA, a target of the Ras/RalGDS pathway negatively regulated the ability of SF to stimulate NF-kappaB activity and cell protection. Ras, Raf1 and RalA modulate SF stimulation of NF-kappaB activity, in part, by regulating IkappaB kinase (IKK)-beta kinase activity. These findings suggest that Ras/Raf1/RalA pathways may converge to modulate NF-kappaB activation and SF-mediated survival signaling at the IKK complex and/or a kinase upstream of this complex. | lld:pubmed |
| pubmed-article:17297451 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17297451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17297451 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17297451 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:17297451 | pubmed:author | pubmed-author:FanSS | lld:pubmed |
| pubmed-article:17297451 | pubmed:author | pubmed-author:MengQQ | lld:pubmed |
| pubmed-article:17297451 | pubmed:author | pubmed-author:RosenE MEM | lld:pubmed |
| pubmed-article:17297451 | pubmed:author | pubmed-author:LaterraJ JJJ | lld:pubmed |
| pubmed-article:17297451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17297451 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:17297451 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17297451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17297451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17297451 | pubmed:pagination | 4774-96 | lld:pubmed |
| pubmed-article:17297451 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17297451 | pubmed:meshHeading | pubmed-meshheading:17297451... | lld:pubmed |
| pubmed-article:17297451 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17297451 | pubmed:articleTitle | Ras effector pathways modulate scatter factor-stimulated NF-kappaB signaling and protection against DNA damage. | lld:pubmed |
| pubmed-article:17297451 | pubmed:affiliation | Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057-1469, USA. | lld:pubmed |
| pubmed-article:17297451 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17297451 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17297451 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17297451 | lld:pubmed |
