| pubmed-article:17296577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17296577 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:17296577 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:17296577 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:17296577 | lifeskim:mentions | umls-concept:C1517917 | lld:lifeskim |
| pubmed-article:17296577 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:17296577 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:17296577 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17296577 | pubmed:dateCreated | 2007-2-13 | lld:pubmed |
| pubmed-article:17296577 | pubmed:abstractText | The aim of this study was to search for hematopoietic potential in the liver of non-human primates. Lethally irradiated (2 x 5 Gy gamma) macaque monkeys were given autologous hepatic mononuclear cells (HMNC) isolated from a liver lobe by perfusion and digestion with 0.1% collagenase. Two monkeys were given intramedullary injections of HMNC (18.6 x 10(6)/kg, 20.4 x 10(6)/kg) and two others were co-transplanted with HMNC (14.35 x 10(6)/kg, 96.5 x 10(6)/kg) and bone marrow mesenchymal stem cells (0.42 x 10(6)/kg, 1.16 x 10(6)/kg). All monkeys exhibited a transient neutrophil recovery from day 22 for 10 days, but failed to produce platelets and remained transfusion-dependent. In conclusion, adult liver stem cells from a monkey model show a low level of in vivo hematopoietic potential, suggesting ex vivo manipulation will be required before clinical use of such cells. | lld:pubmed |
| pubmed-article:17296577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17296577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17296577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17296577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17296577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17296577 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17296577 | pubmed:issn | 1592-8721 | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:ZarskiJean-Pi... | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:NorolFrançois... | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:DrouetMichelM | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:HérodinFranci... | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:LétoublonChri... | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:MayolJean-Fra... | lld:pubmed |
| pubmed-article:17296577 | pubmed:author | pubmed-author:PeinnequinAnd... | lld:pubmed |
| pubmed-article:17296577 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17296577 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:17296577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17296577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17296577 | pubmed:pagination | 248-51 | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:meshHeading | pubmed-meshheading:17296577... | lld:pubmed |
| pubmed-article:17296577 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17296577 | pubmed:articleTitle | Lack of evidence of sustained hematopoietic reconstitution after transplantation of unmanipulated adult liver stem cells in monkeys. | lld:pubmed |
| pubmed-article:17296577 | pubmed:affiliation | Experimental Radiohematology Unit, Centre de Recherches du Service de Santé des Armées, 24 Avenue des Maquis du Grésivaudan, 38702, La Tronche, France. micheldrouet@crssa.net | lld:pubmed |
| pubmed-article:17296577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17296577 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
