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| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0059570 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C1256770 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0235490 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17293480 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17293480 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17293480 | pubmed:dateCreated | 2007-3-16 | lld:pubmed |
| pubmed-article:17293480 | pubmed:abstractText | We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in EpoR(-/-)-rescued mice that lack EpoR in most organs including cardiovascular system except erythroid-lineage cells. Two weeks after femoral artery ligation, blood flow recovery, activation of VEGF/VEGF receptor system, and mobilization of endothelial progenitor cells were all impaired in EpoR(-/-)-rescued mice as compared with wild-type (WT) mice. Bone marrow (BM) transplantation with WT-BM cells in EpoR(-/-)-rescued mice partially but significantly improved blood flow recovery after hindlimb ischemia. The extent of VEGF upregulation and the number of BM-derived cells in ischemic tissue were significantly less in EpoR(-/-)-rescued mice compared with WT mice even after BM reconstitution with WT-BM cells. Similarly, the recovery of blood flow was significantly impaired in recipient EpoR(-/-)-rescued mice that had been transplanted with WT-BM or EpoR(-/-)-rescued-BM as compared with recipient WT mice. Furthermore, the Matrigel implantation assay and aortic ring assay showed that microvessel growth in vitro was significantly reduced in EpoR(-/-)-rescued mice as compared with WT mice. These results indicate that vascular EpoR system also plays an important role in angiogenesis in response to hindlimb ischemia through upregulation of VEGF/VEGF receptor system, both directly by enhancing neovascularization and indirectly by recruiting endothelial progenitor cells and BM-derived proangiogenic cells. | lld:pubmed |
| pubmed-article:17293480 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17293480 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17293480 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17293480 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17293480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17293480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17293480 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17293480 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17293480 | pubmed:issn | 1524-4571 | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:SugamuraKazuo... | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:ShimokawaHiro... | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:KagayaYutakaY | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:IshiiNaotoN | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:FukumotoYoshi... | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:NakanoMakotoM | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:ItoYoshitakaY | lld:pubmed |
| pubmed-article:17293480 | pubmed:author | pubmed-author:SatohKimioK | lld:pubmed |
| pubmed-article:17293480 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17293480 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:17293480 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:17293480 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17293480 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17293480 | pubmed:pagination | 662-9 | lld:pubmed |
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| pubmed-article:17293480 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17293480 | pubmed:articleTitle | Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. | lld:pubmed |
| pubmed-article:17293480 | pubmed:affiliation | Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. fukumoto@cardio.med.tohoku.ac.jp. | lld:pubmed |
| pubmed-article:17293480 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17293480 | pubmed:publicationType | Comparative Study | lld:pubmed |
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