| pubmed-article:17292806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0242402 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0002668 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0043343 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0751608 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17292806 | lifeskim:mentions | umls-concept:C1872034 | lld:lifeskim |
| pubmed-article:17292806 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17292806 | pubmed:dateCreated | 2007-2-12 | lld:pubmed |
| pubmed-article:17292806 | pubmed:abstractText | Prodynorphins (PDYNs) from the African clawed frog (Xenopus laevis), originally described as 'proxendorphins', are novel members of the family of opioid-like precursor polypeptides and were recently discovered based on polymerase chain reaction (PCR) isolates from a Xenopus brain cDNA library. This amphibian prodynorphin was found in two isoforms, (Xen)PDYN-A and (Xen)PDYN-B, consisting of 247 and 279 amino acids, respectively. Each prepropeptide contains five potential opioid-like peptides, collectively named xendorphins. One of these, xendorphin B1 ((Xen)PDYN-B sequence 96-111: YGGFIRKPDKYKFLNA), is a hexadecapeptide that displaced [3H]naloxone and the radiolabelled kappa opioid, [3H]dynorphin A (1-17), with nanomolar affinity from rat brain membranes. Using the acetic acid pain test, the present study examined the antinociceptive effects of spinally administered xendorphin B1 in amphibians. Xendorphin B1 produced a long-lasting and dose-dependent antinociceptive effect in the Northern grass frog (Rana pipiens) with an ED50 value of 44.5 nmol/frog. The antinociceptive effects of xendorphin B1 were significantly blocked by pretreatment with the non-selective opioid antagonist, naltrexone. This is the first report of the in vivo characterization of a non-mammalian prodynorphin-derived peptide and suggests that xendorphin peptides may play a role in the modulation of noxious information in vertebrates. | lld:pubmed |
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| pubmed-article:17292806 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17292806 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17292806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17292806 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17292806 | pubmed:issn | 0361-9230 | lld:pubmed |
| pubmed-article:17292806 | pubmed:author | pubmed-author:BorsodiAnnaA | lld:pubmed |
| pubmed-article:17292806 | pubmed:author | pubmed-author:StevensCraig... | lld:pubmed |
| pubmed-article:17292806 | pubmed:author | pubmed-author:TóthGézaG | lld:pubmed |
| pubmed-article:17292806 | pubmed:author | pubmed-author:BenyheSándorS | lld:pubmed |
| pubmed-article:17292806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17292806 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:17292806 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:17292806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17292806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17292806 | pubmed:pagination | 628-32 | lld:pubmed |
| pubmed-article:17292806 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17292806 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17292806 | pubmed:articleTitle | Xendorphin B1, a novel opioid-like peptide determined from a Xenopus laevis brain cDNA library, produces opioid antinociception after spinal administration in amphibians. | lld:pubmed |
| pubmed-article:17292806 | pubmed:affiliation | Oklahoma State University-Center for Health Sciences, College of Osteopathic Medicine, Tulsa, OK, USA. | lld:pubmed |
| pubmed-article:17292806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17292806 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17292806 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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