| pubmed-article:17292722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17292722 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:17292722 | lifeskim:mentions | umls-concept:C0002888 | lld:lifeskim |
| pubmed-article:17292722 | lifeskim:mentions | umls-concept:C0036001 | lld:lifeskim |
| pubmed-article:17292722 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:17292722 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17292722 | pubmed:dateCreated | 2007-2-12 | lld:pubmed |
| pubmed-article:17292722 | pubmed:abstractText | Impaired methylation due to accumulation of S-adenosylhomocysteine (SAH) may contribute to the pathophysiology of cobalamin-deficient anemia. We assayed serum S-adenosylmethionine (SAM), SAH, total homocysteine (tHcy), and methylmalonic acid (MMA) in 15 subjects with cobalamin-deficient megaloblastic anemia and compared results with those of 19 subjects with anemia/pancytopenia due to other causes. Cobalamin-deficient subjects had a median hematocrit level of 20% and mean cell volume of 111.7 fL. The median serum cobalamin level was 37 pg/mL, MMA 3030 nmol/L, and tHcy 62.0 micromol/L. SAH was elevated in 13 of 15 subjects (median, 42 nmol/L) and the median SAM value was normal (103 nmol/L), but SAM/SAH ratio was low (2.5). The SAH was higher and SAM/SAH ratio was lower in cobalamin-deficient subjects compared with those with other anemias after excluding 4 patients with renal insufficiency. SAM concentrations were not low in cobalamin deficiency. Cobalamin injections corrected anemia, MMA, tHcy, SAM/SAH ratio, and SAH. Some hematologic variables were inversely correlated with SAH and cobalamin but not tHcy or MMA. In conclusion, serum SAH is elevated in cobalamin-deficient subjects with megaloblastic anemia and corrects with parenteral cobalamin therapy. | lld:pubmed |
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| pubmed-article:17292722 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17292722 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292722 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17292722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17292722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17292722 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17292722 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:17292722 | pubmed:author | pubmed-author:StablerSally... | lld:pubmed |
| pubmed-article:17292722 | pubmed:author | pubmed-author:AllenRobert... | lld:pubmed |
| pubmed-article:17292722 | pubmed:author | pubmed-author:Guerra-Shinoh... | lld:pubmed |
| pubmed-article:17292722 | pubmed:author | pubmed-author:MoritaOlga... | lld:pubmed |
| pubmed-article:17292722 | pubmed:author | pubmed-author:PagliusiRegin... | lld:pubmed |
| pubmed-article:17292722 | pubmed:author | pubmed-author:Blaia-d'Avila... | lld:pubmed |
| pubmed-article:17292722 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17292722 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:17292722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17292722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17292722 | pubmed:pagination | 339-47 | lld:pubmed |
| pubmed-article:17292722 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:meshHeading | pubmed-meshheading:17292722... | lld:pubmed |
| pubmed-article:17292722 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17292722 | pubmed:articleTitle | Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemia. | lld:pubmed |
| pubmed-article:17292722 | pubmed:affiliation | Department of Clinical and Toxicological Analysis, Pharmaceutical School, University of São Paulo, São Paulo 05508-900, Brazil. | lld:pubmed |
| pubmed-article:17292722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17292722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
