| pubmed-article:17291741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17291741 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:17291741 | lifeskim:mentions | umls-concept:C2752630 | lld:lifeskim |
| pubmed-article:17291741 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17291741 | pubmed:dateCreated | 2007-3-12 | lld:pubmed |
| pubmed-article:17291741 | pubmed:abstractText | B lymphocyte induced maturation protein 1 (Blimp-1) has long been considered a master regulator of the terminal differentiation of B cells into antibody-secreting plasma cells. Gene-targeting experiments have now demonstrated that quantitative changes in Blimp-1 expression define plasma cell ontogeny--a process that requires the continual function of Blimp-1. Recently, new roles for Blimp-1 have been revealed, as a suppressor of diffuse large B cell lymphoma and as a key regulator of T-cell differentiation. Blimp-1 is expressed in differentiated effector T cells and controls their homeostasis. These new findings suggest that Blimp-1 has a conserved function in the final differentiation of both the cellular and the humoral arm of the adaptive immune response. | lld:pubmed |
| pubmed-article:17291741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17291741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17291741 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17291741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17291741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17291741 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17291741 | pubmed:issn | 0952-7915 | lld:pubmed |
| pubmed-article:17291741 | pubmed:author | pubmed-author:NuttStephen... | lld:pubmed |
| pubmed-article:17291741 | pubmed:author | pubmed-author:KalliesAxelA | lld:pubmed |
| pubmed-article:17291741 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17291741 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:17291741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17291741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17291741 | pubmed:pagination | 156-62 | lld:pubmed |
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| pubmed-article:17291741 | pubmed:meshHeading | pubmed-meshheading:17291741... | lld:pubmed |
| pubmed-article:17291741 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17291741 | pubmed:articleTitle | Terminal differentiation of lymphocytes depends on Blimp-1. | lld:pubmed |
| pubmed-article:17291741 | pubmed:affiliation | The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia. | lld:pubmed |
| pubmed-article:17291741 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17291741 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:17291741 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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