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pubmed-article:17291631pubmed:abstractTextHere we report the study of a new series of peptide-based proteasome inhibitors with a vinyl ester moiety at C-terminal. The presence of Tic, a rigid analogue of phenylalanine, in the central portion of some derivatives is not favourable for the activity. The best analogue of the series shows a potent and selective inhibition for the beta2 subunit and good enzymatic stability.lld:pubmed
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pubmed-article:17291631pubmed:articleTitleGlutamine vinyl ester proteasome inhibitors selective for trypsin-like (beta2) subunit.lld:pubmed
pubmed-article:17291631pubmed:affiliationDepartment of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, Via Fossato di Mortara 17-19, Ferrara, Italy.lld:pubmed
pubmed-article:17291631pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17291631pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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