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pubmed-article:17279949pubmed:dateCreated2007-2-6lld:pubmed
pubmed-article:17279949pubmed:abstractTextThe distribution of inclusion-rich domains in membranes with active two-state inclusions is studied by simulations. Our study shows that typical size of inclusion-rich domains (L) can be controlled by inclusion activities in several ways. When there is effective attraction between state-1 inclusions, we find: (i) Small domains with only several inclusions are observed for inclusions with time scales (approximately 10(-3)s) and interaction energy [approximately Omicron(kBT)] comparable to motor proteins. (ii) L scales as 13 power of the lifetime of state-1 for a wide range of parameters. (iii) L shows a switch-like dependence on state-2 lifetime k12(-1). That is, L depends weakly on k12 when k12<k12* but increases rapidly with k12 when k12>k12*, the crossover k12* occurs when the diffusion length of a typical state-2 inclusion within its lifetime is comparable to L. (iv) Inclusion-curvature coupling provides another length scale that competes with the effects of transition rates.lld:pubmed
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pubmed-article:17279949pubmed:monthNovlld:pubmed
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pubmed-article:17279949pubmed:authorpubmed-author:ChenChien-Hsu...lld:pubmed
pubmed-article:17279949pubmed:authorpubmed-author:ChenHsuan-YiH...lld:pubmed
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pubmed-article:17279949pubmed:year2006lld:pubmed
pubmed-article:17279949pubmed:articleTitleFinite-size domains in membranes with active two-state inclusions.lld:pubmed
pubmed-article:17279949pubmed:affiliationDepartment of Physics, Center for Complex Systems, National Central University, Jhongli, 32054 Taiwan.lld:pubmed
pubmed-article:17279949pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17279949pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed