| pubmed-article:17276676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C0020314 | lld:lifeskim |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C1412186 | lld:lifeskim |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C0796679 | lld:lifeskim |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:17276676 | lifeskim:mentions | umls-concept:C0723595 | lld:lifeskim |
| pubmed-article:17276676 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17276676 | pubmed:dateCreated | 2007-3-13 | lld:pubmed |
| pubmed-article:17276676 | pubmed:abstractText | A new P1' group for TACE inhibitors was identified by eliminating the oxygen atom in the linker of the original 4-(2-methylquinolin-4-ylmethoxy)phenyl P1' group. Incorporation of this 4-(2-methylquinolin-4-ylmethyl)phenyl group onto different beta-aminohydroxamic acid cores provided compound 18, which demonstrated potent porcine TACE (p-TACE) and human whole blood activity, excellent PK properties, and good selectivity against a variety of MMPs. | lld:pubmed |
| pubmed-article:17276676 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17276676 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276676 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17276676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17276676 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17276676 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:CovingtonMary... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:DeciccoCarl... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:TrzaskosJames... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:XueChu-BiaoCB | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:CorbettRonald... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:LiuRui-QinRQ | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:NewtonRobert... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:ChenXiao-TaoX... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:GhavimiBahman... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:ChristDavid... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:DuanJames... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:QianMingxinM | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:RibadeneiraMa... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:VaddiKrishna... | lld:pubmed |
| pubmed-article:17276676 | pubmed:author | pubmed-author:HartmanKarl... | lld:pubmed |
| pubmed-article:17276676 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17276676 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17276676 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17276676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17276676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17276676 | pubmed:pagination | 1865-70 | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
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| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
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| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:meshHeading | pubmed-meshheading:17276676... | lld:pubmed |
| pubmed-article:17276676 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17276676 | pubmed:articleTitle | A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors. | lld:pubmed |
| pubmed-article:17276676 | pubmed:affiliation | Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. xiao-tao.chen@bms.com | lld:pubmed |
| pubmed-article:17276676 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17276676 | lld:chembl |
