pubmed-article:17274685 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C0016832 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C0004037 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C0031307 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C0014406 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
pubmed-article:17274685 | lifeskim:mentions | umls-concept:C1707753 | lld:lifeskim |
pubmed-article:17274685 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:17274685 | pubmed:dateCreated | 2007-5-21 | lld:pubmed |
pubmed-article:17274685 | pubmed:abstractText | The fungal pathogens Aspergillus fumigatus and Candida albicans are major health threats for immune-compromised patients. Normally, macrophages and neutrophil granulocytes phagocytose inhaled Aspergillus conidia in the two-dimensional (2-D) environment of the alveolar lumen or Candida growing in tissue microabscesses, which are composed of a three-dimensional (3-D) extracellular matrix. However, neither the cellular dynamics, the per-cell efficiency, the outcome of this interaction, nor the environmental impact on this process are known. Live imaging shows that the interaction of phagocytes with Aspergillus or Candida in 2-D liquid cultures or 3-D collagen environments is a dynamic process that includes phagocytosis, dragging, or the mere touching of fungal elements. Neutrophils and alveolar macrophages efficiently phagocytosed or dragged Aspergillus conidia in 2-D, while in 3-D their function was severely impaired. The reverse was found for phagocytosis of Candida. The phagocytosis rate was very low in 2-D, while in 3-D most neutrophils internalized multiple yeasts. In competitive assays, neutrophils primarily incorporated Aspergillus conidia in 2-D and Candida yeasts in 3-D despite frequent touching of the other pathogen. Thus, phagocytes show activity best in the environment where a pathogen is naturally encountered. This could explain why "delocalized" Aspergillus infections such as hematogeneous spread are almost uncontrollable diseases, even in immunocompetent individuals. | lld:pubmed |
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pubmed-article:17274685 | pubmed:language | eng | lld:pubmed |
pubmed-article:17274685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17274685 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:17274685 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17274685 | pubmed:month | Feb | lld:pubmed |
pubmed-article:17274685 | pubmed:issn | 1553-7374 | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:RohdeManfredM | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:BilitewskiUrs... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:BrakhageAxel... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:GunzerMatthia... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:BrockMatthias... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:NarangPriyank... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:BehnsenJudith... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:HasenbergMike... | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:GunzerFrankF | lld:pubmed |
pubmed-article:17274685 | pubmed:author | pubmed-author:KlippelNinaN | lld:pubmed |
pubmed-article:17274685 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:17274685 | pubmed:volume | 3 | lld:pubmed |
pubmed-article:17274685 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17274685 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17274685 | pubmed:pagination | e13 | lld:pubmed |
pubmed-article:17274685 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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