| pubmed-article:17270245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17270245 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:17270245 | lifeskim:mentions | umls-concept:C0007115 | lld:lifeskim |
| pubmed-article:17270245 | lifeskim:mentions | umls-concept:C0813143 | lld:lifeskim |
| pubmed-article:17270245 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:17270245 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:17270245 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17270245 | pubmed:dateCreated | 2007-3-19 | lld:pubmed |
| pubmed-article:17270245 | pubmed:abstractText | A radiation etiology is well known in thyroid carcinogenesis. RET oncogene rearrangement is the most common oncogenic alteration in Chernobyl-related papillary thyroid cancer (PTC). To find the characteristic alteration associated with RET rearrangements in radiation-induced thyroid cancers, we analyzed the RET oncogene by fluorescence in situ hybridization. The fluorescence in situ hybridization technique has the possibility of detecting RET rearrangements at a single-cell level regardless of the specific fusion partner involved and directly reveals RET copy number on a per-cell basis. Our study demonstrated RET amplification in all 3 cases of radiation-associated thyroid cancers but not in sporadic well-differentiated PTC (n = 11). Furthermore, RET amplification was observed in all 6 cases of sporadic anaplastic thyroid cancers (ATCs). The frequency of RET amplification-positive cells was higher in ATC (7.2%-24.1%) than in PTC (1.5%-2.7%). The highest frequency of RET amplification-positive cells was observed among ATC cases with a strong p53 immunoreactivity. In conclusion, we found RET amplification, which is a rare oncogenic aberration, in thyroid cancer. This report is the first one to suggest the presence of RET amplification in PTC and ATC. RET amplification was correlated with radiation-associated, high-grade malignant potency, and p53 accumulation, suggesting genomic instability. RET amplification might be induced by a high level of genomic instability in connection with progression of thyroid carcinogenesis and, subsequently, be associated with radiation-induced and/or high-grade malignant cases. | lld:pubmed |
| pubmed-article:17270245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17270245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17270245 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17270245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17270245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17270245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17270245 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17270245 | pubmed:issn | 0046-8177 | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:NakashimaMasa... | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:SekineIchiroI | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:HayashiTomayo... | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:MatsumotoNaom... | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:MaedaShigetoS | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:NambaHiroyuki... | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:TakamuraNobor... | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:MeirmanovSeri... | lld:pubmed |
| pubmed-article:17270245 | pubmed:author | pubmed-author:SaenkoVladimi... | lld:pubmed |
| pubmed-article:17270245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17270245 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:17270245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17270245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17270245 | pubmed:pagination | 621-8 | lld:pubmed |
| pubmed-article:17270245 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
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| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:meshHeading | pubmed-meshheading:17270245... | lld:pubmed |
| pubmed-article:17270245 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17270245 | pubmed:articleTitle | RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy. | lld:pubmed |
| pubmed-article:17270245 | pubmed:affiliation | Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan. moemoe@nagasaki-u.ac.jp | lld:pubmed |
| pubmed-article:17270245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17270245 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5979 | entrezgene:pubmed | pubmed-article:17270245 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17270245 | lld:pubmed |
