| pubmed-article:17268554 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C0001038 | lld:lifeskim |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C1420556 | lld:lifeskim |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C1424530 | lld:lifeskim |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17268554 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:17268554 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17268554 | pubmed:dateCreated | 2007-2-21 | lld:pubmed |
| pubmed-article:17268554 | pubmed:abstractText | Transforming growth factor-beta (TGF-beta) family members are multifunctional growth factors involved in regulating diverse biological processes. Despite the critical role for TGF-beta in regulating cell proliferation, differentiation, migration and development, its role in regulating NF-kappaB-dependent inflammatory response still remains unclear. Here, we show that TGF-beta1 induces acetylation of NF-kappaB p65 subunit to synergistically enhance bacterium nontypeable Haemophilus influenzae-induced NF-kappaB activation and inflammatory response in vitro and in vivo. The TGF-beta1-induced acetylation of p65 is mediated via a Smad3/4-PKA-p300-dependent signaling pathway. Acetylation of p65 at lysine 221 by TGF-beta1 is critical for synergistic enhancement of bacteria-induced DNA-binding activity, NF-kappaB activation, NF-kappaB-dependent transcription of TNF-alpha and IL-1beta and interstitial polymorphonuclear neutrophil infiltration in vitro and in vivo. These studies provide new insights into the novel regulation of NF-kappaB by TGF-beta signaling. | lld:pubmed |
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| pubmed-article:17268554 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17268554 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17268554 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17268554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17268554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17268554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17268554 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17268554 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17268554 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:DaleT JTJ | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:LiJian-DongJD | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:FengXin-HuaXH | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:KweonSoo-MiSM | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:XuHaodongH | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:JonoHirofumiH | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:XuHaidongH | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:IshinagaHajim... | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:ChenLin-FengL... | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:HaUn-HwanUH | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:LimJae... | lld:pubmed |
| pubmed-article:17268554 | pubmed:author | pubmed-author:KogaTomoakiT | lld:pubmed |
| pubmed-article:17268554 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17268554 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:17268554 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17268554 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17268554 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17268554 | pubmed:pagination | 1150-62 | lld:pubmed |
| pubmed-article:17268554 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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