| pubmed-article:17261627 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C2338991 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0010654 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0039341 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1883712 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:17261627 | lifeskim:mentions | umls-concept:C0142328 | lld:lifeskim |
| pubmed-article:17261627 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17261627 | pubmed:dateCreated | 2007-4-23 | lld:pubmed |
| pubmed-article:17261627 | pubmed:abstractText | Previous studies have shown that peptides containing the protein transduction domain (PTD) of the human immunodeficiency virus tat protein (GRKKRRQRRR) were effective inhibitors of herpes simplex virus type 1 (HSV-1) entry (H. Bultmann and C. R. Brandt, J. Biol. Chem. 277:36018-36023, 2002). We now show that the addition of a single cysteine residue to the C terminus of the TAT PTD (TAT-C peptide) improves the antiviral activity against HSV-1 and HSV-2. The principle effect of adding the cysteine was to enable the peptide to inactivate virions and to induce a state of resistance to infection in cells pretreated with peptide. The TAT-C peptide acted extracellularly, immediately blocked entry of adsorbed virus, prevented VP16 translocation to the nucleus, and blocked syncytium formation and cell-cell spread. Thus, TAT-C peptides are fusion inhibitors. The induction of the resistance of cells to infection was rapid, recovered with a half-life of 5 to 6 h, and could be reinduced by peptide treatment. TAT-C bound to heparan sulfate but was a poor competitor for viral attachment. The antiviral activity depended on the net positive charge of the peptide but not on chirality, and a free sulfhydryl group was not essential for antiviral activity because TAT-C dimers were at least as effective as monomers. The unique combination of antiviral activities and low toxicity combine to make TAT-C a strong candidate for further development as a drug to block HSV infection. | lld:pubmed |
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| pubmed-article:17261627 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17261627 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17261627 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17261627 | pubmed:month | May | lld:pubmed |
| pubmed-article:17261627 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:17261627 | pubmed:author | pubmed-author:BrandtCurtis... | lld:pubmed |
| pubmed-article:17261627 | pubmed:author | pubmed-author:BultmannHerma... | lld:pubmed |
| pubmed-article:17261627 | pubmed:author | pubmed-author:TeutonJeremyJ | lld:pubmed |
| pubmed-article:17261627 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17261627 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:17261627 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17261627 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17261627 | pubmed:pagination | 1596-607 | lld:pubmed |
| pubmed-article:17261627 | pubmed:dateRevised | 2010-8-26 | lld:pubmed |
| pubmed-article:17261627 | pubmed:meshHeading | pubmed-meshheading:17261627... | lld:pubmed |
