| pubmed-article:17259983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17259983 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:17259983 | lifeskim:mentions | umls-concept:C1414028 | lld:lifeskim |
| pubmed-article:17259983 | lifeskim:mentions | umls-concept:C2613185 | lld:lifeskim |
| pubmed-article:17259983 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:17259983 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17259983 | pubmed:dateCreated | 2007-2-27 | lld:pubmed |
| pubmed-article:17259983 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17259983 | pubmed:abstractText | The molecular controls that govern the differentiation of embryonic stem (ES) cells remain poorly understood. DGCR8 is an RNA-binding protein that assists the RNase III enzyme Drosha in the processing of microRNAs (miRNAs), a subclass of small RNAs. Here we study the role of miRNAs in ES cell differentiation by generating a Dgcr8 knockout model. Analysis of mouse knockout ES cells shows that DGCR8 is essential for biogenesis of miRNAs. On the induction of differentiation, DGCR8-deficient ES cells do not fully downregulate pluripotency markers and retain the ability to produce ES cell colonies; however, they do express some markers of differentiation. This phenotype differs from that reported for Dicer1 knockout cells, suggesting that Dicer has miRNA-independent roles in ES cell function. Our findings indicate that miRNAs function in the silencing of ES cell self-renewal that normally occurs with the induction of differentiation. | lld:pubmed |
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| pubmed-article:17259983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17259983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17259983 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17259983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17259983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17259983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17259983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17259983 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17259983 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:17259983 | pubmed:author | pubmed-author:JaenischRudol... | lld:pubmed |
| pubmed-article:17259983 | pubmed:author | pubmed-author:WangYangmingY | lld:pubmed |
| pubmed-article:17259983 | pubmed:author | pubmed-author:BlellochRober... | lld:pubmed |
| pubmed-article:17259983 | pubmed:author | pubmed-author:MedvidRostisl... | lld:pubmed |
| pubmed-article:17259983 | pubmed:author | pubmed-author:MeltonCollinC | lld:pubmed |
| pubmed-article:17259983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17259983 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:17259983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17259983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17259983 | pubmed:pagination | 380-5 | lld:pubmed |
| pubmed-article:17259983 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
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| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
| pubmed-article:17259983 | pubmed:meshHeading | pubmed-meshheading:17259983... | lld:pubmed |
| pubmed-article:17259983 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17259983 | pubmed:articleTitle | DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. | lld:pubmed |
| pubmed-article:17259983 | pubmed:affiliation | Developmental and Stem Cell Biology Program, Department of Urology, University of California, San Francisco, California 94143, USA. | lld:pubmed |
| pubmed-article:17259983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17259983 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17259983 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17259983 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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