| pubmed-article:17259397 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C1956346 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0037293 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0441994 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C1420799 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C0181496 | lld:lifeskim |
| pubmed-article:17259397 | lifeskim:mentions | umls-concept:C1522485 | lld:lifeskim |
| pubmed-article:17259397 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17259397 | pubmed:dateCreated | 2007-1-29 | lld:pubmed |
| pubmed-article:17259397 | pubmed:abstractText | A20 or tumor necrosis factor (TNF)-induced protein 3 (TNFAIP3) is a negative regulator of nuclear factor-kappaB (NF-kappaB). We have investigated whether polymorphisms in this gene are associated with increased atherosclerosis in diabetic patients. Five tag single nucleotide polymorphisms (SNPs) were typed in 479 type 2 diabetic patients from Boston, including 239 coronary artery disease (CAD)-positive case subjects and 240 CAD-negative control subjects. Two tag SNPs (rs5029930 and rs610604) were independently associated with CAD; adjusted odds ratios (ORs) for minor allele carriers were 2.3 (95% CI 1.4-3.8, P = 0.001) and 2.0 (1.3-2.9, P = 0.0008), respectively. The association with rs610604 was dependent on glycemic control, with ORs of 3.9 among subjects with A1C < or =7.0% and 1.2 for those with A1C >7.0% (P for interaction = 0.015). A similar interaction pattern was found among 231 CAD-positive and 332 CAD-negative type 2 diabetic patients from Italy (OR 2.2, P = 0.05 vs. OR 0.9, P = 0.63 in the low vs. high A1C strata, P for interaction = 0.05). Quantitative RT-PCR in blood mononuclear cells from 83 nondiabetic subjects showed that rs610604 and rs5029930 minor allele homozygotes have 30-45% lower levels of A20 mRNA than major allele homozygotes, and heterozygotes have intermediate levels (P = 0.04 and 0.028, respectively). These findings point to variability in the A20/TNFAIP3 gene as a modulator of CAD risk in type 2 diabetes. This effect is mediated by allelic differences in A20 expression. | lld:pubmed |
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| pubmed-article:17259397 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17259397 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17259397 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17259397 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17259397 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17259397 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:Boonyasrisawa... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:TrischittaVin... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:ShoelsonSteve... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:DoriaAlessand... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:BacciSimonett... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:ZhangYuan-Yua... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:NolanDavidD | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:JohnstoneMich... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:GervinoErnest... | lld:pubmed |
| pubmed-article:17259397 | pubmed:author | pubmed-author:EberleDelphin... | lld:pubmed |
| pubmed-article:17259397 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17259397 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:17259397 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17259397 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17259397 | pubmed:pagination | 499-505 | lld:pubmed |
| pubmed-article:17259397 | pubmed:dateRevised | 2011-2-3 | lld:pubmed |
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| pubmed-article:17259397 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17259397 | pubmed:articleTitle | Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. | lld:pubmed |
| pubmed-article:17259397 | pubmed:affiliation | Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA. | lld:pubmed |
| pubmed-article:17259397 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17259397 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17259397 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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