Linked Life Data

1725692

Source:http://linkedlifedata.com/resource/pubmed/id/1725692

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1725692rdf:typepubmed:Citationlld:pubmed
pubmed-article:1725692lifeskim:mentionsumls-concept:C0035366lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0027160lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0032594lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C1167398lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0598312lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C1422036lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0002518lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0486616lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0443199lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0032521lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:1725692lifeskim:mentionsumls-concept:C1521840lld:lifeskim
pubmed-article:1725692pubmed:issue12lld:pubmed
pubmed-article:1725692pubmed:dateCreated1992-5-28lld:pubmed
pubmed-article:1725692pubmed:abstractTextSulfated polysaccharides (i.e., dextran sulfate) and sulfated polymers (i.e., sulfated polyvinylalcohol and sulfated copolymers of acrylic acid with vinylalcohol) were found to be potent and selective inhibitors of the replication of respiratory syncytial virus (RSV) and influenza virus type A (influenza A virus) but not of other myxoviruses (parainfluenza 3, measles, and influenza B viruses). The compounds were also inhibitory to human immunodeficiency virus type 1 (HIV-1) and HIV-2 and simian immunodeficiency virus but not simian AIDS-related virus. The mode of antiviral action of the sulfated polysaccharides and polymers can be attributed to an inhibition of virus binding to the cells (HIV-1), inhibition of virus-cell fusion (influenza A virus), or inhibition of both virus-cell binding and fusion (RSV). The fact that the sulfated polysaccharides and polymers are inhibitory to some myxoviruses and retroviruses but not to others seems to depend on the composition of the amino acid sequences of the viral envelope glycoproteins that are involved in virus-cell binding and fusion. All myxoviruses and retroviruses that are sensitive to the sulfated polysaccharides and polymers share a tripeptide segment (Phe-Leu-Gly). This tripeptide segment may be involved either directly (as a target sequence) or indirectly in the inhibitory effects of the compounds on virus-cell binding and fusion.lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:languageenglld:pubmed
pubmed-article:1725692pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:citationSubsetIMlld:pubmed
pubmed-article:1725692pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1725692pubmed:statusMEDLINElld:pubmed
pubmed-article:1725692pubmed:monthDeclld:pubmed
pubmed-article:1725692pubmed:issn0066-4804lld:pubmed
pubmed-article:1725692pubmed:authorpubmed-author:De ClercqEElld:pubmed
pubmed-article:1725692pubmed:authorpubmed-author:ShigetaSSlld:pubmed
pubmed-article:1725692pubmed:authorpubmed-author:BalzariniJJlld:pubmed
pubmed-article:1725692pubmed:authorpubmed-author:HosoyaMMlld:pubmed
pubmed-article:1725692pubmed:issnTypePrintlld:pubmed
pubmed-article:1725692pubmed:volume35lld:pubmed
pubmed-article:1725692pubmed:ownerNLMlld:pubmed
pubmed-article:1725692pubmed:authorsCompleteYlld:pubmed
pubmed-article:1725692pubmed:pagination2515-20lld:pubmed
pubmed-article:1725692pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:meshHeadingpubmed-meshheading:1725692-...lld:pubmed
pubmed-article:1725692pubmed:year1991lld:pubmed
pubmed-article:1725692pubmed:articleTitleDifferential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins.lld:pubmed
pubmed-article:1725692pubmed:affiliationRega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.lld:pubmed
pubmed-article:1725692pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1725692pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1725692lld:pubmed