| pubmed-article:17254556 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17254556 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:17254556 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:17254556 | lifeskim:mentions | umls-concept:C2361980 | lld:lifeskim |
| pubmed-article:17254556 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:17254556 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17254556 | pubmed:dateCreated | 2007-2-2 | lld:pubmed |
| pubmed-article:17254556 | pubmed:abstractText | We tested whether glucocorticoids modulated osteoblast expression of the annexin 1 system, including the ligand and two G-coupled receptors termed formyl-peptide receptor (FPR) and FPR-like-1 (FPRL-1). In Saos-2 cells, rapid up-regulation of FPR mRNA upon cell incubation with dexamethasone (0.01-1 microM) was observed, with significant changes as early as 2h and a more marked response at 24h; annexin 1 and FPRL-1 mRNA changes were more subtle. At the protein level, dexamethasone provoked a rapid externalization of annexin 1 (maximal at 2h) followed by delayed time-dependent changes in the cell cytosol. Saos-2 cell surface expression of FPR or FPRL-1 could not be detected, even when dexamethasone was added with the bone modelling cytokines interleukin-6 or interleukin-1. The uneven modulation of the annexin 1 system (mediator and its putative receptors) in osteoblasts might lead to a better understanding of how these complex biochemical pathways become operative in bone. | lld:pubmed |
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| pubmed-article:17254556 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17254556 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17254556 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17254556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17254556 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17254556 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17254556 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:17254556 | pubmed:author | pubmed-author:ManciniLuciaL | lld:pubmed |
| pubmed-article:17254556 | pubmed:author | pubmed-author:PerrettiMauro... | lld:pubmed |
| pubmed-article:17254556 | pubmed:author | pubmed-author:GinerRosa MRM | lld:pubmed |
| pubmed-article:17254556 | pubmed:author | pubmed-author:KamalAhmad... | lld:pubmed |
| pubmed-article:17254556 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17254556 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:17254556 | pubmed:volume | 354 | lld:pubmed |
| pubmed-article:17254556 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17254556 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17254556 | pubmed:pagination | 414-9 | lld:pubmed |
| pubmed-article:17254556 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:meshHeading | pubmed-meshheading:17254556... | lld:pubmed |
| pubmed-article:17254556 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17254556 | pubmed:articleTitle | Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone. | lld:pubmed |
| pubmed-article:17254556 | pubmed:affiliation | Departmento de Farmacologia, Universitat de Valéncia, València, Spain. | lld:pubmed |
| pubmed-article:17254556 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17254556 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17254556 | lld:pubmed |
