| pubmed-article:17252135 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17252135 | lifeskim:mentions | umls-concept:C0005036 | lld:lifeskim |
| pubmed-article:17252135 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17252135 | lifeskim:mentions | umls-concept:C0022203 | lld:lifeskim |
| pubmed-article:17252135 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17252135 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17252135 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17252135 | pubmed:dateCreated | 2007-1-25 | lld:pubmed |
| pubmed-article:17252135 | pubmed:abstractText | Enantiopure trans-dihydrodiols have been obtained by a chemoenzymatic synthesis from the corresponding cis-dihydrodiol metabolites, obtained by dioxygenase-catalysed arene cis-dihydroxylation at the 2,3-bond of monosubstituted benzene substrates. This generally applicable, seven-step synthetic route to trans-dihydrodiols involves a regioselective hydrogenation and a Mitsunobu inversion of configuration at C-2, followed by benzylic bromination and dehydrobromination steps. The method has also been extended to the synthesis of both enantiomers of the trans-dihydrodiol derivatives of toluene, through substitution of a vinyl bromine atom of the corresponding trans-dihydrodiol enantiomers derived from bromobenzene. Through incorporation of hydrogenolysis and diMTPA ester diastereoisomer resolution steps into the synthetic route, both trans-dihydrodiol enantiomers of monohalobenzenes were obtained from the cis-dihydrodiols of 4-haloiodobenzenes. | lld:pubmed |
| pubmed-article:17252135 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17252135 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17252135 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17252135 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17252135 | pubmed:issn | 1477-0520 | lld:pubmed |
| pubmed-article:17252135 | pubmed:author | pubmed-author:BoydDerek RDR | lld:pubmed |
| pubmed-article:17252135 | pubmed:author | pubmed-author:SharmaNarain... | lld:pubmed |
| pubmed-article:17252135 | pubmed:author | pubmed-author:AllenChristop... | lld:pubmed |
| pubmed-article:17252135 | pubmed:author | pubmed-author:LlamasNuria... | lld:pubmed |
| pubmed-article:17252135 | pubmed:author | pubmed-author:CoenGerard... | lld:pubmed |
| pubmed-article:17252135 | pubmed:author | pubmed-author:McGeehinPeter... | lld:pubmed |
| pubmed-article:17252135 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17252135 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:17252135 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:17252135 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17252135 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17252135 | pubmed:pagination | 514-22 | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:meshHeading | pubmed-meshheading:17252135... | lld:pubmed |
| pubmed-article:17252135 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17252135 | pubmed:articleTitle | Chemoenzymatic synthesis of trans-dihydrodiol derivatives of monosubstituted benzenes from the corresponding cis-dihydrodiol isomers. | lld:pubmed |
| pubmed-article:17252135 | pubmed:affiliation | School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UK BT9 5AG. dr.boyd@qub.ac.uk | lld:pubmed |
| pubmed-article:17252135 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17252135 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
