| pubmed-article:17237824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C1070653 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C1425143 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C1427590 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:17237824 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:17237824 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:17237824 | pubmed:dateCreated | 2007-6-21 | lld:pubmed |
| pubmed-article:17237824 | pubmed:abstractText | p53-upregulated modulator of apoptosis (PUMA) is a BH3-only Bcl-2 family protein and an essential mediator of DNA damage-induced apoptosis. PUMA is localized in the mitochondria and induces apoptosis through the mitochondrial pathway. However, the mechanisms of PUMA-induced apoptosis remain unclear. In this study, we found that second mitochondria-derived activator of caspase (SMAC)/Diablo, a mitochondrial apoptogenic protein, mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events. SMAC is consistently released into the cytosol in colon cancer cells undergoing PUMA-induced apoptosis. In SMAC-deficient cells, execution of PUMA-induced apoptosis is abrogated, in company with decreases in caspase activation, cytosolic release of cytochrome c and collapse of mitochondrial membrane potential. Reconstituting SMAC expression restored these events in the SMAC-deficient cells. Furthermore, SMAC and agents that mimic the inhibitor of apoptosis proteins (IAPs) inhibition function of SMAC significantly sensitize cells to PUMA-induced apoptosis. These results demonstrate an important role of SMAC in executing DNA damage-induced and PUMA-mediated apoptosis and suggest that SMAC participates in a feedback amplification loop to promote cytochrome c release and other mitochondrial events in apoptosis. | lld:pubmed |
| pubmed-article:17237824 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17237824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17237824 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17237824 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:17237824 | pubmed:author | pubmed-author:WandSS | lld:pubmed |
| pubmed-article:17237824 | pubmed:author | pubmed-author:YuJJ | lld:pubmed |
| pubmed-article:17237824 | pubmed:author | pubmed-author:WoodM AMA | lld:pubmed |
| pubmed-article:17237824 | pubmed:author | pubmed-author:MineJJ | lld:pubmed |
| pubmed-article:17237824 | pubmed:author | pubmed-author:ZhangLL | lld:pubmed |
| pubmed-article:17237824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17237824 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:17237824 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17237824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17237824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17237824 | pubmed:pagination | 4189-98 | lld:pubmed |
| pubmed-article:17237824 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:meshHeading | pubmed-meshheading:17237824... | lld:pubmed |
| pubmed-article:17237824 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17237824 | pubmed:articleTitle | SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events. | lld:pubmed |
| pubmed-article:17237824 | pubmed:affiliation | Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. | lld:pubmed |
| pubmed-article:17237824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17237824 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17237824 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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