| pubmed-article:17229501 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0699819 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0086022 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0442117 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C1705099 | lld:lifeskim |
| pubmed-article:17229501 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:17229501 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17229501 | pubmed:dateCreated | 2007-2-16 | lld:pubmed |
| pubmed-article:17229501 | pubmed:abstractText | Gut-associated lymphoid tissue (GALT) is the primary replication site for HIV-1, resulting in a pronounced CD4(+) T cell loss in this tissue during primary infection. A mucosal vaccine that generates HIV-specific CD8(+) T cells in the gut could prevent the establishment of founder populations and broadcasting of virus. Here, we immunized mice orally and systemically with a chimpanzee derived adenoviral vector expressing HIV gag (AdC68gag) and measured frequencies of gag-specific interferon-gamma (IFN-gamma) producing CD8(+) T cells in the GALT. A single oral administration was inefficient at eliciting responses in the mesenteric lymph nodes and Peyer's Patches, while a single intramuscular administration elicited strong systemic and detectable mucosal responses. The gag-specific CD8(+) T cell responses were present in both acute and memory phases following intramuscular administration. | lld:pubmed |
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| pubmed-article:17229501 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17229501 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229501 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17229501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229501 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17229501 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17229501 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:17229501 | pubmed:author | pubmed-author:ErtlH CHC | lld:pubmed |
| pubmed-article:17229501 | pubmed:author | pubmed-author:LinS WSW | lld:pubmed |
| pubmed-article:17229501 | pubmed:author | pubmed-author:CunA SAS | lld:pubmed |
| pubmed-article:17229501 | pubmed:author | pubmed-author:Harris-McCoyK... | lld:pubmed |
| pubmed-article:17229501 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17229501 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17229501 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17229501 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17229501 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17229501 | pubmed:pagination | 2187-93 | lld:pubmed |
| pubmed-article:17229501 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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