| pubmed-article:17228025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0041427 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0344335 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17228025 | lifeskim:mentions | umls-concept:C1335816 | lld:lifeskim |
| pubmed-article:17228025 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17228025 | pubmed:dateCreated | 2007-1-17 | lld:pubmed |
| pubmed-article:17228025 | pubmed:abstractText | Src-homology-2 (SH2)-B, a Janus tyrosine kinase 2-interacting protein, has been identified recently as a key regulator of leptin and insulin sensitivity, glucose homeostasis, and body weight in mice. The aim of this study was to determine whether single-nucleotide polymorphisms (SNPs) in the human SH2B gene are associated with these variables. A tagging SNP (tSNP), Ala484Thr (rs7498665), was selected to represent five common SNPs (minor allele frequency > 0.05) in perfect linkage disequilibrium in a 16-kb region encompassing the SH2B gene. The tSNP was genotyped in 2455 white female twins (mean age, 47.4 +/- 12.6 years) from the St. Thomas' United Kingdom Adult Twin Registry (Twins United Kingdom). Ala484Thr (minor allele frequency, 0.38) was associated with serum leptin, total fat, waist circumference, and body weight (P = 0.02 to 0.04). The coding SNP has no predicted effect on protein structure or function and is likely to be in linkage disequilibrium with an as-yet unidentified functional variant in the SH2B gene. Our results support a role for SH2-B in modulating the regulation of body weight and fat by leptin in this female population. If SH2-B signaling is attenuated in diet-induced obesity, it could become a target for drug-induced leptin sensitization. | lld:pubmed |
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| pubmed-article:17228025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17228025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17228025 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17228025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17228025 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17228025 | pubmed:issn | 1930-7381 | lld:pubmed |
| pubmed-article:17228025 | pubmed:author | pubmed-author:SpectorTim... | lld:pubmed |
| pubmed-article:17228025 | pubmed:author | pubmed-author:JamshidiYalda... | lld:pubmed |
| pubmed-article:17228025 | pubmed:author | pubmed-author:SniederHarold... | lld:pubmed |
| pubmed-article:17228025 | pubmed:author | pubmed-author:O'DellSandra... | lld:pubmed |
| pubmed-article:17228025 | pubmed:author | pubmed-author:GeDongliangD | lld:pubmed |
| pubmed-article:17228025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17228025 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17228025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17228025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17228025 | pubmed:pagination | 5-9 | lld:pubmed |
| pubmed-article:17228025 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17228025 | pubmed:meshHeading | pubmed-meshheading:17228025... | lld:pubmed |
| pubmed-article:17228025 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17228025 | pubmed:articleTitle | The SH2B gene is associated with serum leptin and body fat in normal female twins. | lld:pubmed |
| pubmed-article:17228025 | pubmed:affiliation | Nutrition Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. | lld:pubmed |
| pubmed-article:17228025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17228025 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17228025 | pubmed:publicationType | Twin Study | lld:pubmed |
| entrez-gene:25970 | entrezgene:pubmed | pubmed-article:17228025 | lld:entrezgene |
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