| pubmed-article:17227438 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17227438 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:17227438 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17227438 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:17227438 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:17227438 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:17227438 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:17227438 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17227438 | pubmed:dateCreated | 2007-1-17 | lld:pubmed |
| pubmed-article:17227438 | pubmed:abstractText | Epidemiological studies indicate that smoking is a negative, and exposure to pesticides, a positive risk factor for Parkinson's disease (PD). The purpose of this study was to assess the interplay between these two factors in a rodent model of nigrostriatal damage. To approach this, mice were administered nicotine, the agent in smoke implicated in neuroprotection. They were then treated for 3 weeks with the pesticide, paraquat, while nicotine was continued. Paraquat treatment decreased (25%) nigral dopaminergic neurons, consistent with previous results. Chronic nicotine administration significantly protected against nigral cell damage, with only a 16% decline in mice treated with both nicotine and paraquat. Paraquat treatment also decreased (14%) the striatal dopamine transporter, an effect that was partially prevented by nicotine. These changes in the striatal dopamine transporter paralleled those in a select striatal alpha6beta2* nicotinic receptor (nAChR) subtype. In contrast, striatal alpha4beta2* nAChRs were not decreased with paraquat treatment, suggesting they are on a differential subset of dopaminergic terminals. The results show that nicotine treatment partially protects against paraquat-induced declines in nigrostriatal dopaminergic neurons to which a select population of alpha6beta2* nAChRs are localized. Moreover, these data support epidemiological findings that environmental influences can elicit opposing effects on nigrostriatal dopaminergic integrity. | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17227438 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17227438 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17227438 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17227438 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:17227438 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:17227438 | pubmed:author | pubmed-author:McIntoshJ... | lld:pubmed |
| pubmed-article:17227438 | pubmed:author | pubmed-author:QuikMarykaM | lld:pubmed |
| pubmed-article:17227438 | pubmed:author | pubmed-author:McCormackAlis... | lld:pubmed |
| pubmed-article:17227438 | pubmed:author | pubmed-author:KhwajaMiriumM | lld:pubmed |
| pubmed-article:17227438 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17227438 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:17227438 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17227438 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17227438 | pubmed:pagination | 180-90 | lld:pubmed |
| pubmed-article:17227438 | pubmed:dateRevised | 2011-9-22 | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:meshHeading | pubmed-meshheading:17227438... | lld:pubmed |
| pubmed-article:17227438 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17227438 | pubmed:articleTitle | Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs. | lld:pubmed |
| pubmed-article:17227438 | pubmed:affiliation | The Parkinson's Institute, Sunnyvale, CA 94089, USA. | lld:pubmed |
| pubmed-article:17227438 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17227438 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17227438 | lld:pubmed |
