| pubmed-article:17220916 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17220916 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17220916 | lifeskim:mentions | umls-concept:C1336692 | lld:lifeskim |
| pubmed-article:17220916 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17220916 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17220916 | pubmed:dateCreated | 2007-1-29 | lld:pubmed |
| pubmed-article:17220916 | pubmed:abstractText | When associated with different receptors, the signalling adaptor DAP12 has been shown to both potentiate and attenuate the activation of leukocytes. But how can a protein with a single signalling motif elicit qualitatively different cellular responses? We describe a model of DAP12 function, whereby the quality of the cellular response (activation or inhibition) is modulated by the avidity of the interaction between the DAP12-associated receptor and its ligand. This model extends from previous studies of inhibitory signalling mediated by other adaptors, such as the Fc-receptor gamma-chain and CD3zeta, and provides a potential mechanism for the conflicting phenotypes observed in studies of DAP12-deficient mice. | lld:pubmed |
| pubmed-article:17220916 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17220916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17220916 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17220916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17220916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17220916 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17220916 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17220916 | pubmed:issn | 1474-1733 | lld:pubmed |
| pubmed-article:17220916 | pubmed:author | pubmed-author:ColonnaMarcoM | lld:pubmed |
| pubmed-article:17220916 | pubmed:author | pubmed-author:TurnbullIsaia... | lld:pubmed |
| pubmed-article:17220916 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17220916 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:17220916 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17220916 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17220916 | pubmed:pagination | 155-61 | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:meshHeading | pubmed-meshheading:17220916... | lld:pubmed |
| pubmed-article:17220916 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17220916 | pubmed:articleTitle | Activating and inhibitory functions of DAP12. | lld:pubmed |
| pubmed-article:17220916 | pubmed:affiliation | Washington University School of Medicine, Department of Pathology and Immunology, Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. | lld:pubmed |
| pubmed-article:17220916 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17220916 | pubmed:publicationType | Review | lld:pubmed |
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