| pubmed-article:17218791 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C1706586 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C0031678 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C0812215 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C2746015 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17218791 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17218791 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17218791 | pubmed:dateCreated | 2007-2-1 | lld:pubmed |
| pubmed-article:17218791 | pubmed:abstractText | The Raf-1 kinase is an effector of Ras GTPases that lies at the apex of the three-tier Raf/MEK/ERK pathway. Raf-1 activation is a complex process that entails two major events--relief of autoinhibition imposed by the regulatory domain and kinase domain activation. Recent studies indicate that the transition of Raf-1 from an active to an inactive state bears similar complexity to the activation process. Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signaling. | lld:pubmed |
| pubmed-article:17218791 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17218791 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17218791 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17218791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17218791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17218791 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17218791 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17218791 | pubmed:issn | 1551-4005 | lld:pubmed |
| pubmed-article:17218791 | pubmed:author | pubmed-author:DhillonAmarde... | lld:pubmed |
| pubmed-article:17218791 | pubmed:author | pubmed-author:KolchWalterW | lld:pubmed |
| pubmed-article:17218791 | pubmed:author | pubmed-author:GrindlayJoanJ | lld:pubmed |
| pubmed-article:17218791 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:17218791 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17218791 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17218791 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:17218791 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17218791 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17218791 | pubmed:pagination | 3-7 | lld:pubmed |
| pubmed-article:17218791 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:meshHeading | pubmed-meshheading:17218791... | lld:pubmed |
| pubmed-article:17218791 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17218791 | pubmed:articleTitle | Phosphatase and feedback regulation of Raf-1 signaling. | lld:pubmed |
| pubmed-article:17218791 | pubmed:affiliation | Signaling and Proteomics Group, Beatson Institute for Cancer Research, Glasgow, UK. A.Dhillon@beatson.gla.ac.uk | lld:pubmed |
| pubmed-article:17218791 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17218791 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:17218791 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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