| pubmed-article:1721243 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1721243 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1721243 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:1721243 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:1721243 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:1721243 | lifeskim:mentions | umls-concept:C0679823 | lld:lifeskim |
| pubmed-article:1721243 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:1721243 | pubmed:issue | 5038 | lld:pubmed |
| pubmed-article:1721243 | pubmed:dateCreated | 1992-1-21 | lld:pubmed |
| pubmed-article:1721243 | pubmed:abstractText | Long-term depression (LTD) in the intact cerebellum is a decrease in the efficacy of the parallel fiber-Purkinje neuron synapse induced by coactivation of climbing fiber and parallel fiber inputs. In cultured Purkinje neurons, a similar depression can be induced by iontophoretic glutamate pulses and Purkinje neuron depolarization. This form of LTD is expressed as a depression of alpha-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA)-mediated current, and its induction is dependent on activation of metabotropic quisqualate receptors. The effect of inhibitors of protein kinase C (PKC) on LTD induction was studied. Inhibitors of PKC blocked LTD induction, while phorbol-12,13-diacetate (PDA), a PKC activator, mimicked LTD. These results suggest that PKC activation is necessary for the induction of cerebellar LTD. | lld:pubmed |
| pubmed-article:1721243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1721243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1721243 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1721243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1721243 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1721243 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:1721243 | pubmed:author | pubmed-author:ConnorJ AJA | lld:pubmed |
| pubmed-article:1721243 | pubmed:author | pubmed-author:LindenD JDJ | lld:pubmed |
| pubmed-article:1721243 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1721243 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:1721243 | pubmed:volume | 254 | lld:pubmed |
| pubmed-article:1721243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1721243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1721243 | pubmed:pagination | 1656-9 | lld:pubmed |
| pubmed-article:1721243 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1721243 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1721243 | pubmed:articleTitle | Participation of postsynaptic PKC in cerebellar long-term depression in culture. | lld:pubmed |
| pubmed-article:1721243 | pubmed:affiliation | Department of Neurosciences, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110. | lld:pubmed |
| pubmed-article:1721243 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1721243 | pubmed:publicationType | In Vitro | lld:pubmed |
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