Linked Life Data

17197436

Source:http://linkedlifedata.com/resource/pubmed/id/17197436

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pubmed-article:17197436pubmed:abstractTextCCR6, a homeostatic chemokine receptor, is shown here to characterize subsets of both central and effector memory T cells that secrete high levels of IL-2 and TNF-alpha in response to polyclonal and antigen-specific stimulation. CCR6(+) T lymphocytes disappeared dramatically from the peripheral blood of HIV-infected patients as HIV disease progressed. The capacity of CD4(+)CCR6(+) to secrete multiple cytokines remained intact among HIV-infected long-term nonprogressors but was partially lost from subjects with standard disease progression. CCR6(+) T lymphocytes, regardless of their CCR7 expression, accumulated in the spleen of HIV-infected patients, where they died by apoptosis. Assessment of CCR6 expression allowed us to describe novel memory T-cell subpopulations capable of high cytokine production and provided evidence of a pathologic CCR6-dependent pathway of memory T-cell homing that may participate in the loss of memory response against infections.lld:pubmed
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pubmed-article:17197436pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:17197436pubmed:year2007lld:pubmed
pubmed-article:17197436pubmed:articleTitleTrapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients.lld:pubmed
pubmed-article:17197436pubmed:affiliationINSERM U543, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine, Université Pierre et Marie Curie-Paris 6, Paris, France.lld:pubmed
pubmed-article:17197436pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:17197436pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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