Linked Life Data

1719315

Source:http://linkedlifedata.com/resource/pubmed/id/1719315

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pubmed-article:1719315pubmed:abstractTextThere are few data on mucosal immune responses to intestinal helminths in human beings, especially those involving the IgE system, which is thought to be important in parasite expulsion. We sought evidence of an immediate hypersensitivity reaction in the colon of children with chronic dysentery due to Trichuris trichiura. 28 children with Trichuris dysentery syndrome (TDS) were compared with 16 control children (with no TDS or worms visible on colonoscopy). All children were aged 1-11 years. Rectal biopsy samples were taken before and after expulsion of the worms by means of mebendazole treatment. Children with TDS had significantly greater numbers than controls of mast cells (mean [SD] 10.9 [1.3] vs 3.9 [0.6]% of all cells; p less than 0.0003) and of cells with surface IgE (median [range] 11.1 [7.5-11.6] vs 1.0 [0-1.5]%; p less than 0.001) in the subepithelial region of the mucosa. On electronmicroscopy, degranulating mast cells were prominent in parasitised children. In culture, rectal biopsy samples from parasitised children showed high rates of spontaneous histamine release, but only low rates of antigen-specific release. After treatment, spontaneous histamine release was significantly reduced and antigen-specific histamine release could be provoked. Thus, an IgE-mediated immune mucosal response to a helminth infection does occur in human beings but is not sufficient to cause appreciable parasite expulsion.lld:pubmed
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pubmed-article:1719315pubmed:dateRevised2009-9-29lld:pubmed
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pubmed-article:1719315pubmed:articleTitleImmediate hypersensitivity in colon of children with chronic Trichuris trichiura dysentery.lld:pubmed
pubmed-article:1719315pubmed:affiliationDepartment of Biology, Imperial College of Science, Technology and Medicine, London, UK.lld:pubmed
pubmed-article:1719315pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1719315pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:1719315pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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