| pubmed-article:17185998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C0011991 | lld:lifeskim |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C0007292 | lld:lifeskim |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C1412077 | lld:lifeskim |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:17185998 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:17185998 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17185998 | pubmed:dateCreated | 2006-12-22 | lld:pubmed |
| pubmed-article:17185998 | pubmed:abstractText | Interindividual pharmacokinetic variability of the anticancer agent irinotecan is high. Life-threatening diarrhea is observed in up to 25% of patients receiving irinotecan and has been related with irinotecan pharmacokinetics and UGT1A1 genotype status. Here, we explore the association of ABCC2 (MRP2) polymorphisms and haplotypes with irinotecan disposition and diarrhea. A cohort of 167 Caucasian cancer patients who were previously assessed for irinotecan pharmacokinetics (90-min infusion given every 21 days), toxicity, and UGT1A1*28 genotype were genotyped for polymorphisms in ABCC2 using Pyrosequencing. Fifteen ABCC2 haplotypes were identified in the studied patients. The haplotype ABCC2*2 was associated with lower irinotecan clearance (28.3 versus 31.6 l/h; P=0.020). In patients who did not carry a UGT1A1*28 allele, a significant reduction of severe diarrhea was noted in patients with the ABCC2*2 haplotype (10 versus 44%; odds ratio, 0.15; 95% confidence interval, 0.04-0.61; P=0.005). This effect was not observed in patients with at least one UGT1A1*28 allele (32 versus 20%; odds ratio, 1.87; 95% confidence interval, 0.49-7.05; P=0.354). This study suggests that the presence of the ABCC2*2 haplotype is associated with less irinotecan-related diarrhea, maybe as a consequence of reduced hepatobiliary secretion of irinotecan. As the association was seen in patients not genetically predisposed at risk for diarrhea due to UGT1A1*28, confirmatory studies of the relationships of ABCC2 genotypes and irinotecan disposition and toxicity are warranted. | lld:pubmed |
| pubmed-article:17185998 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17185998 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17185998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17185998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17185998 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17185998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17185998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17185998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17185998 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17185998 | pubmed:issn | 0009-9236 | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:MarshSS | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:McLeodH LHL | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:VerweijJJ | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:de JongF AFA | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:KroetzD LDL | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:SparreboomAA | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:MathijssenR... | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:FribergL ELE | lld:pubmed |
| pubmed-article:17185998 | pubmed:author | pubmed-author:Scott-HortonT... | lld:pubmed |
| pubmed-article:17185998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17185998 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:17185998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17185998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17185998 | pubmed:pagination | 42-9 | lld:pubmed |
| pubmed-article:17185998 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17185998 | pubmed:meshHeading | pubmed-meshheading:17185998... | lld:pubmed |
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| pubmed-article:17185998 | pubmed:meshHeading | pubmed-meshheading:17185998... | lld:pubmed |
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| pubmed-article:17185998 | pubmed:meshHeading | pubmed-meshheading:17185998... | lld:pubmed |
| pubmed-article:17185998 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17185998 | pubmed:articleTitle | Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. | lld:pubmed |
| pubmed-article:17185998 | pubmed:affiliation | Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. | lld:pubmed |
| pubmed-article:17185998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17185998 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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