| pubmed-article:17184942 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0009195 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0205093 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0032405 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C1428200 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0677535 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17184942 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17184942 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:17184942 | pubmed:dateCreated | 2007-1-29 | lld:pubmed |
| pubmed-article:17184942 | pubmed:abstractText | Sound can damage peripheral cochlear function through a number of mechanisms, and emerging evidence suggests that inflammation may be one of them. Using immunohistochemistry and poly (ADP-ribose) polymerase-1 (PARP-1) mutant mice, we tested whether PARP-1 contributes to loud-sound induced cochlear lateral wall damage by triggering inflammatory effects, including upregulating intercellular adhesion molecule-1 (ICAM-1), P-selectin and platelet-endothelial cell-adhesion molecule-1 (PECAM-1). In control conditions, we found that there was no detectable poly-ADP-ribose (PAR) in the marginal cells and microvessels. ICAM-1 was expressed only at low levels in the vessels of the stria vascularis and the spiral ligament. P-selectin and PECAM-1 were barely detected and only in the vessels of the spiral ligament. Following loud-sound exposure, PAR was detected in numbers of marginal cells and some vessels of the spiral ligament. Also, an elevated expression of ICAM-1 was demonstrated in some vessels of the stria vascularis and spiral ligament. Increased expression of P-selectin and PECAM-1 were mainly located in the vessels of the spiral ligament, while increased populations of non-migrated and migrated leukocytes were observed in the area of the spiral ligament. However, neither increased expression of adhesion proteins nor increased population of leukocytes, were observed in the PARP-1 knockout mouse. We thus conclude that loud-sound stress activates the expression of adhesion molecular proteins in the lateral wall and that PARP-1 modulates inflammation-linked protein expression and leukocyte migration. | lld:pubmed |
| pubmed-article:17184942 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17184942 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17184942 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17184942 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17184942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17184942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17184942 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17184942 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17184942 | pubmed:issn | 0378-5955 | lld:pubmed |
| pubmed-article:17184942 | pubmed:author | pubmed-author:NuttallAlfred... | lld:pubmed |
| pubmed-article:17184942 | pubmed:author | pubmed-author:ShiXiaoruiX | lld:pubmed |
| pubmed-article:17184942 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17184942 | pubmed:volume | 224 | lld:pubmed |
| pubmed-article:17184942 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17184942 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17184942 | pubmed:pagination | 1-14 | lld:pubmed |
| pubmed-article:17184942 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17184942 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17184942 | pubmed:articleTitle | Expression of adhesion molecular proteins in the cochlear lateral wall of normal and PARP-1 mutant mice. | lld:pubmed |
| pubmed-article:17184942 | pubmed:affiliation | Oregon Hearing Research Center (NRC04), Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC04, Portland, OR 97239-3098, USA. | lld:pubmed |
| pubmed-article:17184942 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17184942 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:11545 | entrezgene:pubmed | pubmed-article:17184942 | lld:entrezgene |
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