| pubmed-article:17183697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C1706479 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C1235660 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C1334516 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C1520113 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C0872241 | lld:lifeskim |
| pubmed-article:17183697 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:17183697 | pubmed:dateCreated | 2007-1-8 | lld:pubmed |
| pubmed-article:17183697 | pubmed:abstractText | Over the past few years, it has become increasingly apparent that signal transduction pathways are not merely linear cascades; they are organized into complex signaling networks that require high levels of regulation to generate precise and unique cell responses. However, the underlying regulatory mechanisms by which signaling pathways cross-communicate remain poorly understood. Here we show that the Ras-binding protein Canoe (Cno)/AF-6, a PDZ protein normally associated with cellular junctions, is a key modulator of Wingless (Wg)/Wnt, Ras-Mitogen Activated Protein Kinase (MAPK) and Notch (N) signaling pathways cross-communication. Our data show a repressive effect of Cno/AF-6 on these three signaling pathways through physical interactions with Ras, N and the cytoplasmic protein Dishevelled (Dsh), a key Wg effector. We propose a model in which Cno, through those interactions, actively coordinates, at the membrane level, Ras-MAPK, N and Wg signaling pathways during progenitor specification. | lld:pubmed |
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| pubmed-article:17183697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17183697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183697 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17183697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17183697 | pubmed:issn | 1932-6203 | lld:pubmed |
