| pubmed-article:17182670 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0392674 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C1334123 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17182670 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17182670 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17182670 | pubmed:dateCreated | 2007-2-26 | lld:pubmed |
| pubmed-article:17182670 | pubmed:abstractText | The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8+ antiviral T-cell exhaustion and may contribute to inadequate pathogen control. To investigate whether human CD8+ T cells express PD-1 and demonstrate a dysfunctional phenotype during chronic HCV infection, peripheral and intrahepatic HCV-specific CD8+ T cells were examined. We found that in chronic HCV infection, peripheral HCV-specific T cells express high levels of PD-1 and that blockade of the PD-1/PD-L1 interaction led to an enhanced proliferative capacity. Importantly, intrahepatic HCV-specific T cells, in contrast to those in the periphery, express not only high levels of PD-1 but also decreased interleukin-7 receptor alpha (CD127), an exhausted phenotype that was HCV antigen specific and compartmentalized to the liver, the site of viral replication. | lld:pubmed |
| pubmed-article:17182670 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17182670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17182670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17182670 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17182670 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17182670 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:RouseBarry... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:AltmanJohn... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:FreemanGordon... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:AhmedRafiR | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:WherryE... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:SteinbergJame... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:MasopustDavid... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:WehbiMohammad... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:WorkowskiKimb... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:GrakouiArashA | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:HansonHolly... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:RadziewiczHen... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:IbegbuChris... | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:ObideenKamilK | lld:pubmed |
| pubmed-article:17182670 | pubmed:author | pubmed-author:FernandezMari... | lld:pubmed |
