| pubmed-article:17178920 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C0754728 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:17178920 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:17178920 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17178920 | pubmed:dateCreated | 2006-12-27 | lld:pubmed |
| pubmed-article:17178920 | pubmed:abstractText | Commensalism is critical to a healthy Th1/Th2 cell balance. Polysaccharide A (PSA), which is produced by the intestinal commensal Bacteroides fragilis, activates CD4+ T cells, resulting in a Th1 response correcting the Th2 cell skew of germ-free mice. We identify Toll-like receptors as crucial to the convergence of innate and adaptive responses stimulated by PSA. Optimization of the Th1 cytokine interferon-gamma in PSA-stimulated dendritic cell-CD4+ T cell co-cultures depends on both Toll-like receptor (TLR) 2 and antigen presentation. Synergy between the innate and adaptive responses was also shown when TLR2-/- mice exhibited impaired intraabdominal abscess formation in response to B. fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways. | lld:pubmed |
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| pubmed-article:17178920 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17178920 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17178920 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17178920 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17178920 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:McLoughlinRac... | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:CobbBrian ABA | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:KasperDennis... | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:TzianabosArth... | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:WangQunQ | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:GolenbockDoug... | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:Charrel-Denni... | lld:pubmed |
| pubmed-article:17178920 | pubmed:author | pubmed-author:ZaleskiKathle... | lld:pubmed |
| pubmed-article:17178920 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17178920 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:17178920 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:17178920 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17178920 | pubmed:authorsComplete | Y | lld:pubmed |
