| pubmed-article:17178895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C1458155 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:17178895 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17178895 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17178895 | pubmed:dateCreated | 2006-12-20 | lld:pubmed |
| pubmed-article:17178895 | pubmed:abstractText | Activated growth factor receptor tyrosine kinases (RTK) play pivotal roles in a variety of human cancers, including breast cancer. Ron, a member of the Met RTK proto-oncogene family, is overexpressed or constitutively active in 50% of human breast cancers. To define the significance of Ron overexpression and activation in vivo, we generated transgenic mice that overexpress a wild-type or constitutively active Ron receptor in the mammary epithelium. In these animals, Ron expression is significantly elevated in mammary glands and leads to a hyperplastic phenotype by 12 weeks of age. Ron overexpression is sufficient to induce mammary transformation in all transgenic animals and is associated with a high degree of metastasis, with metastatic foci detected in liver and lungs of >86% of all transgenic animals. Furthermore, we show that Ron overexpression leads to receptor phosphorylation and is associated with elevated levels of tyrosine phosphorylated beta-catenin and the up-regulation of genes, including cyclin D1 and c-myc, which are associated with poor prognosis in patients with human breast cancers. These studies suggest that Ron overexpression may be a causative factor in breast tumorigenesis and provides a model to dissect the mechanism by which the Ron induces transformation and metastasis. | lld:pubmed |
| pubmed-article:17178895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17178895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17178895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17178895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17178895 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17178895 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:WaltzSusan... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:CollinsMargar... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:LeonisMike... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:PathrosePeter... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:ZinserGlendon... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:BeaumanShirel... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:PeaceBelinda... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:KaderSarah... | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:ToneyKenyaK | lld:pubmed |
| pubmed-article:17178895 | pubmed:author | pubmed-author:ThobeMeganM | lld:pubmed |
| pubmed-article:17178895 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17178895 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17178895 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:17178895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17178895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17178895 | pubmed:pagination | 11967-74 | lld:pubmed |
| pubmed-article:17178895 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:meshHeading | pubmed-meshheading:17178895... | lld:pubmed |
| pubmed-article:17178895 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17178895 | pubmed:articleTitle | Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. | lld:pubmed |
| pubmed-article:17178895 | pubmed:affiliation | Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45267, USA. | lld:pubmed |
| pubmed-article:17178895 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17178895 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17178895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17178895 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:19882 | entrezgene:pubmed | pubmed-article:17178895 | lld:entrezgene |
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