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pubmed-article:17177837pubmed:dateCreated2006-12-20lld:pubmed
pubmed-article:17177837pubmed:abstractTextCervical cancer patients with histologically documented re-recurrence after curative salvage therapy or unexplained tumor marker elevation (negative computed tomography and/or magnetic resonance imaging [CT-MRI]) proven to be a re-recurrence when a further attempt for cure (or control of cancer) appeared feasible were enrolled. Lesion status was determined from pathology or clinical follow-up for at least 12 months. Management decisions were recorded with CT-MRI alone and incorporating [18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), respectively. The benefits calculated were based on clinical impact because of the FDG-PET findings. Cox proportional hazards model was used to select independent prognostic covariates. Of the 26 patients who were eligible for analysis, 12 (46.2%) patients had positive impacts due to PET. Squamous cell carcinoma (SCC, P = 0.029), re-recurrence at distant metastasis only (P = 0.012), and level of SCC antigen < or = 4 ng/mL (P = 0.005) were significantly associated with better survival. A scoring system using these covariates defined three distinct prognostic groups (P = 0.0001). Patients with score 0 had a 36-month cumulative survival rate of 80%. Using this prognostic scoring system, FDG-PET may facilitate selecting appropriate management for the individual patient with re-recurrent cervical cancer.lld:pubmed
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pubmed-article:17177837pubmed:articleTitleRole of [18F]fluoro-2-deoxy-D-glucose positron emission tomography in re-recurrent cervical cancer.lld:pubmed
pubmed-article:17177837pubmed:affiliationDepartments of Obstetrics and Gynecology, Nuclear Medicine, Diagnostic Radiology, and Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.lld:pubmed
pubmed-article:17177837pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17177837pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed