| pubmed-article:17174923 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17174923 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:17174923 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:17174923 | lifeskim:mentions | umls-concept:C2263154 | lld:lifeskim |
| pubmed-article:17174923 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:17174923 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17174923 | pubmed:dateCreated | 2006-12-18 | lld:pubmed |
| pubmed-article:17174923 | pubmed:abstractText | The Rho family of GTPases regulates many aspects of cellular behavior through alterations to the actin cytoskeleton . The majority of the Rho family proteins function as molecular switches cycling between the active, GTP-bound and the inactive, GDP-bound conformations . Unlike typical Rho-family proteins, the Rnd subfamily members, including Rnd1, Rnd2, RhoE (also known as Rnd3), and RhoH, are GTPase deficient and are thus expected to be constitutively active . Here, we identify an unexpected role for RhoE/Rnd3 in the regulation of the p53-mediated stress response. We show that RhoE is a transcriptional p53 target gene and that genotoxic stress triggers actin depolymerization, resulting in actin-stress-fiber disassembly through p53-dependent RhoE induction. Silencing of RhoE induction in response to genotoxic stress maintains stress fiber formation and strikingly increases apoptosis, implying an antagonistic role for RhoE in p53-dependent apoptosis. We found that RhoE inhibits ROCK I (Rho-associated kinase I) activity during genotoxic stress and thereby suppresses apoptosis. We demonstrate that the p53-mediated induction of RhoE in response to DNA damage favors cell survival partly through inhibition of ROCK I-mediated apoptosis. Thus, RhoE is anticipated to function by regulating ROCK I signaling to control the balance between cell survival and cell death in response to genotoxic stress. | lld:pubmed |
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| pubmed-article:17174923 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17174923 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17174923 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17174923 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17174923 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17174923 | pubmed:issn | 0960-9822 | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:SalehM NMN | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:DottoG... | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:DerChanning... | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:KimYoung-BumY... | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:RidleyAnne... | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:AaronsonStuar... | lld:pubmed |
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| pubmed-article:17174923 | pubmed:author | pubmed-author:BoswellSarah... | lld:pubmed |
| pubmed-article:17174923 | pubmed:author | pubmed-author:KimHyung-GuHG | lld:pubmed |
| pubmed-article:17174923 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17174923 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:17174923 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:17174923 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17174923 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17174923 | pubmed:pagination | 2466-72 | lld:pubmed |
| pubmed-article:17174923 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:17174923 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17174923 | pubmed:articleTitle | RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. | lld:pubmed |
| pubmed-article:17174923 | pubmed:affiliation | Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA. | lld:pubmed |
| pubmed-article:17174923 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17174923 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17174923 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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