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pubmed-article:1717048pubmed:abstractTextLight deprivation of rat retina leads to a rapid (within 6 h) development of a state of supersensitivity (upregulation) of dopamine D-1 receptors (positively coupled to adenylate cyclase), which are essentially involved in the modulation by light of the electrical activity and communication between horizontal cells. In contrast, the supersensitivity of D-2 receptors (negatively coupled to cAMP generating system) appears to develop only after 2 days (better after 4 days) of dark adaptation, although these receptors are linked to multiple light-dependent retinal functions. These results suggest the existence of different mechanisms of sensory adaptation for these two subtypes of dopamine receptors.lld:pubmed
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pubmed-article:1717048pubmed:articleTitleDark-induced supersensitivity of dopamine D-1 and D-2 receptors in rat retina.lld:pubmed
pubmed-article:1717048pubmed:affiliationDepartment of Biogenic Amines, Polish Academy of Sciences, Lodz.lld:pubmed
pubmed-article:1717048pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1717048pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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