| pubmed-article:17166723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0002771 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C1417756 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0036557 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0031959 | lld:lifeskim |
| pubmed-article:17166723 | lifeskim:mentions | umls-concept:C0631330 | lld:lifeskim |
| pubmed-article:17166723 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17166723 | pubmed:dateCreated | 2007-1-17 | lld:pubmed |
| pubmed-article:17166723 | pubmed:abstractText | A series of 3-phenoxypropyl piperidine benzimidazol-2-one analogues have been discovered as novel NOP receptor agonists. Structure-activity relationships have been explored via N-3 substitution of the benzimidazol-2-one with a range of functionality. The N-methyl acetamide derivative (+)-7f was found to be a high-affinity, potent NOP agonist with greater than 100-fold selectivity over the MOP receptor. Furthermore (+)-7f was shown to be both antinociceptive and sedative when administered iv to rodents. | lld:pubmed |
| pubmed-article:17166723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17166723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17166723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17166723 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17166723 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:JonesPhilip... | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:BomAntonA | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:ClarkJohn KJK | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:FeildenHelenH | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:PalinRonaldR | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:EvansLouiseL | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:MontgomeryBri... | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:HoughtonAndre... | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:WestonMark... | lld:pubmed |
| pubmed-article:17166723 | pubmed:author | pubmed-author:WishartGrantG | lld:pubmed |
| pubmed-article:17166723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17166723 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17166723 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17166723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17166723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17166723 | pubmed:pagination | 1828-47 | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:meshHeading | pubmed-meshheading:17166723... | lld:pubmed |
| pubmed-article:17166723 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17166723 | pubmed:articleTitle | Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties. | lld:pubmed |
| pubmed-article:17166723 | pubmed:affiliation | Department of Chemistry, Organon Laboratories Ltd., Newhouse, Lanarkshire ML1 5SH, UK. r.palin@organon.co.uk | lld:pubmed |
| pubmed-article:17166723 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17166723 | lld:chembl |
