| pubmed-article:17166181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C1416473 | lld:lifeskim |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:17166181 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:17166181 | pubmed:issue | Pt 3 | lld:pubmed |
| pubmed-article:17166181 | pubmed:dateCreated | 2007-4-19 | lld:pubmed |
| pubmed-article:17166181 | pubmed:abstractText | Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors that control the transactivation of type I interferon system-related genes, as well as the expression of several other genes involved in immune response, cell signalling, cell cycle control and apoptosis. Two recent studies reported a significant association between the IRF5/rs2004640 T allele and systemic lupus erythematosus (SLE). The purpose of this study was to determine whether the reported rs2004640 T allele association could be replicated in our independent SLE case-control sample. We genotyped DNA samples from 370 white SLE-affected female subjects and 462 white healthy female controls using the TaqMan Assay-on-Demand for rs2004640, and performed a case-control genetic association analysis. Frequency of the rs2004640 T allele was significantly higher in cases than in controls (56.5% vs. 50%; P= 0.008). The odds ratio for T allele carriers was 1.68 (95% CI: 1.20 - 2.34; P= 0.003). Our results in an independent case-control sample confirm the robust association of the IRF5/rs2004640 T allele with SLE risk, and further support the relevance of the type I interferon system in the pathogenesis of SLE and autoimmunity. | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17166181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17166181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17166181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17166181 | pubmed:month | May | lld:pubmed |
| pubmed-article:17166181 | pubmed:issn | 0003-4800 | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:KarA KAK | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:KenneyMM | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:KambohM IMI | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:Ramsey-Goldma... | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:BontempoFF | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:ManziSS | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:KammererCC | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:ShawP SPS | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:RhewEE | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:MinsterR LRL | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:DemirciF Y... | lld:pubmed |
| pubmed-article:17166181 | pubmed:author | pubmed-author:Dunlop-Thomas... | lld:pubmed |
| pubmed-article:17166181 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17166181 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:17166181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17166181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17166181 | pubmed:pagination | 308-11 | lld:pubmed |
| pubmed-article:17166181 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17166181 | pubmed:meshHeading | pubmed-meshheading:17166181... | lld:pubmed |
| pubmed-article:17166181 | pubmed:meshHeading | pubmed-meshheading:17166181... | lld:pubmed |
| pubmed-article:17166181 | pubmed:meshHeading | pubmed-meshheading:17166181... | lld:pubmed |
| pubmed-article:17166181 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17166181 | pubmed:articleTitle | Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE). | lld:pubmed |
| pubmed-article:17166181 | pubmed:affiliation | Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. | lld:pubmed |
| pubmed-article:17166181 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17166181 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:17166181 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:3663 | entrezgene:pubmed | pubmed-article:17166181 | lld:entrezgene |
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